PIWIL2

  • Official Full Name

    piwi-like RNA-mediated gene silencing 2

  • Overview

    Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Plays an essential role in meiotic differentiation of spermatocytes, germ cell differentiation and in self-renewal of spermatogonial stem cells. Its presence in oocytes suggests that it may participate to similar functions during oogenesis in females. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Associates with primary piRNAs in the cytoplasm and is required for PIWIL4/MIWI2 nuclear localization and association with secondary piRNAs antisense. The piRNA process acts upstream of known mediators of DNA methylation. Participates to a piRNA amplification loop. Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation. Indirectly modulate expression of genes such as PDGFRB, SLC2A1, ITGA6, GJA7, THY1, CD9 and STRA8. Inhibits tumor cell growth when repressed. When overexpressed, acts as an oncogene by inhibition of apoptosis and promotion of proliferation in tumors.

  • Synonyms

    PIWIL2;piwi-like RNA-mediated gene silencing 2;mili;Piwil1l;piwi-like protein 2;Miwi like;Miwi likw;piwi like homolog 2;piwi-like homolog 2

Recombinant Proteins

  • Human
  • Mouse
  • Rhesus macaque
  • Zebrafish
  • E.coli
  • Mammalian Cells
  • HEK293
  • His
  • Non
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
PIWIL2-1737H Recombinant Human PIWIL2 protein, His-tagged E.coli Human His 662-973 aa
PIWIL2-12853M Recombinant Mouse PIWIL2 Protein Mammalian Cells Mouse His
PIWIL2-3444R Recombinant Rhesus monkey PIWIL2 Protein, His-tagged Mammalian Cells Rhesus macaque His
PIWIL2-5055Z Recombinant Zebrafish PIWIL2 Mammalian Cells Zebrafish His
PIWIL2-1360HCL Recombinant Human PIWIL2 cell lysate Human Non
PIWIL2-3262R Recombinant Rhesus Macaque PIWIL2 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque His&Fc&Avi
PIWIL2-3262R-B Recombinant Rhesus Macaque PIWIL2 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
PIWIL2-6773M Recombinant Mouse PIWIL2 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
PIWIL2-6773M-B Recombinant Mouse PIWIL2 Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    PIWIL2 involved in several pathways and played different roles in them. We selected most pathways PIWIL2 participated on our site, such as Dorso-ventral axis formation, which may be useful for your reference. Also, other proteins which involved in the same pathway with PIWIL2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Dorso-ventral axis formation ETV7,PPP1R2P9,ETS2,CPEB3,EGFRA,MAPK3,GRB2,NOTCH1,CPEB1A,FMN2

    Protein Function

    PIWIL2 has several biochemical functions, for example, mRNA binding,piRNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PIWIL2 itself. We selected most functions PIWIL2 had, and list some proteins which have the same functions with PIWIL2. You can find most of the proteins on our site.

    Function Related Protein
    mRNA binding TRA2B,ZFP36,RPS13,CSTF2T,SOSTDC1B,FYTTD1,RBMX,FMR1,ELAVL1,UHMK1
    piRNA binding PIWIL4,PIWIL1

    Interacting Protein

    PIWIL2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PIWIL2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PIWIL2.

    b4dyc6_human;HSP90AA1;STIP1;FKBP5;PTGES3;HSP90AB1;q96be0_human;PPP5C;AARSD1

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