PITX3
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Official Full Name
paired-like homeodomain 3 -
Overview
This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. Members of this family act as transcription factors. This protein is involved in lens formation during eye development. Mutations of this gene have been associated with anterior segment mesenchymal dysgenesis and congenital cataracts. -
Synonyms
PITX3;paired-like homeodomain 3;paired like homeodomain transcription factor 3;pituitary homeobox 3;homeobox protein PITX3;PTX3;CTPP4;MGC12766
Recombinant Proteins
- Zebrafish
- Mouse
- Rat
- Human
- Mammalian Cell
- E.coli
- HEK293
- Yeast
- His
- His&GST
- Non
- His&Fc&Avi
- GST
Involved Pathway
PITX3 involved in several pathways and played different roles in them. We selected most pathways PITX3 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PITX3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
PITX3 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding,transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PITX3 itself. We selected most functions PITX3 had, and list some proteins which have the same functions with PITX3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | NKX2-5,ATF4,KCNIP3,TBX15,RFX2,PHOX2B,MXD1,TBX20,DLX4,MYPOP |
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | HLTF,TFAM,YBX1,SP1,ESR1,NR5A2,ATOH1,DLX3,PATZ1,NOBOX |
Interacting Protein
PITX3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PITX3 here. Most of them are supplied by our site. Hope this information will be useful for your research of PITX3.
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