PITX2
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Official Full Name
paired-like homeodomain 2 -
Overview
This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. The encoded protein acts as a transcription factor and regulates procollagen lysyl hydroxylase gene expression. This protein plays a role in the terminal differentiation of somatotroph and lactotroph cell phenotypes, is involved in the development of the eye, tooth and abdominal organs, and acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. Mutations in this gene are associated with Axenfeld-Rieger syndrome, iridogoniodysgenesis syndrome, and sporadic cases of Peters anomaly. A similar protein in other vertebrates is involved in the determination of left-right asymmetry during development. Alternatively spliced transcript variants encoding distinct isoforms have been described. -
Synonyms
PITX2;paired-like homeodomain 2;IHG2, IRID2, paired like homeodomain transcription factor 2 , RGS, RIEG, RIEG1;pituitary homeobox 2;ARP1;Brx1;IGDS;Otlx2;RS;All1 responsive gene 1;ALL1 responsive protein ARP1;ALL1-responsive protein ARP1;ARP 1;Brx 1;Homeobox protein PITX2;IDG 2;IDG2;IGDS 2;IGDS2;IHG 2;IHG2;IRID 2;IRID2;MGC111022;MGC20144;Otlx 2;Paired like homeodomain transcription factor 2;Paired-like homeodomain transcription factor 2;Pituitary homeo box 2;PITX 2;PITX2_HUMAN;PTX 2;PTX2;RGS;RIEG 1;RIEG;Rieg bicoid related homeobox transcription factor 1;RIEG bicoid related homeobox transcription factor;RIEG bicoid-related homeobox transcription factor;RIEG1;Solurshin;OTTHUMP00000163734;OTTHUMP00000163735;OTTHUMP00000163736;OTTHUMP00000163737;OTTHUMP00000163738;OTTHUMP00000219750;OTTHUMP00000219751;all1-responsive gene 1;ALL1-responsive protein
Recombinant Proteins
- Mouse
- Human
- Rat
- Chicken
- Zebrafish
- Mammalian Cell
- E.coli
- HEK293
- His
- His&GST
- HIS
- Non
- His&Fc&Avi
Involved Pathway
PITX2 involved in several pathways and played different roles in them. We selected most pathways PITX2 participated on our site, such as TGF-beta signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PITX2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| TGF-beta signaling pathway | TGFB3,INHBAB,TGFB2,ID2B,TGFBR2,BMP8B,RBL1,BMP6,NODAL,AMHR2 |
Protein Function
PITX2 has several biochemical functions, for example, RNA polymerase II activating transcription factor binding,RNA polymerase II core promoter proximal region sequence-specific DNA binding,RNA polymerase II transcription coactivator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PITX2 itself. We selected most functions PITX2 had, and list some proteins which have the same functions with PITX2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding | BACH1,TBX3,NEUROG3,NKX3-2,PROX1B,ZNF217,JDP2,IFI16,TGIF1,ZGPAT |
| transcription factor binding | NR0B2,KCNA3,GCM1,RORA,CSNK2B,NCOA2,KDM1A,HEYL,FOXF2,MAFB |
| identical protein binding | APPL1,GOT1L1,KCTD13,PRPF19,RILPL2,Serpina1b,S100B,ALDH4A1,CALCA,CEP57L1 |
| transcription factor activity, sequence-specific DNA binding | TBX2A,SALL1A,NOTCH1,CSRNP2,NFAT5A,HES1,TBX24,ELF3,ESR2A,PKNOX1 |
| RNA polymerase II activating transcription factor binding | CTNNB1,NFE2L2,EP300,MAD2L2,JUN,ZFPM1,TBX6,TBX20,TP53BP1,CREB1 |
| phosphoprotein binding | LYN,TBK1,SERPINB1A,SFN,PAFAH1B1,LRP11,SAG,MTOR,APTX,GPRIN1 |
| protein homodimerization activity | TDG,CTSE,MYPOP,RIPK2,SRGAP2,S100A10,SH3GLB1,FLT3,NBL1,GDNFA |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | ALS2CR8,SPI1,IFI203,JDP2,ETV6,TFE3B,JUNBB,RBPJL,E2F4,CC2D1A |
| transcriptional repressor activity, RNA polymerase II transcription factor binding | BHLHE40,ELP2,CREBBP,RIMKLB,TBX6,AHRRB,AHRRA,EOMES,MLIP,MINA |
Interacting Protein
PITX2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PITX2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PITX2.
Hoxa1;CTNNB1;YBX1;PRKACB;RFC2;CDC37;GPR158;MYC;NCL;HNRNPK;HNRNPU
Resources
Research Area
Cancer Stem Cell Transcription FactorsHematopoietic Stem Cell Transcription Factors and Regulators
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References
- Watson, S; Sarris, M; et al. Limbal Dermoid Epithelium Shares Phenotypic Characteristics Common to Both Hair Epidermal and Limbal Epithelial Stem Cells. CURRENT EYE RESEARCH 38:835-842(2013).
- Hatayama, M; Mikoshiba, K; et al. IP3 signaling is required for cilia formation and left-right body axis determination in Xenopus embryos. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 410:520-524(2011).
