PIK3R5
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Official Full Name
phosphoinositide-3-kinase, regulatory subunit 5 -
Overview
Phosphatidylinositol 3-kinases (PI3Ks) phosphorylate the inositol ring of phosphatidylinositol at the 3-prime position, and play important roles in cell growth, proliferation, differentiation, motility, survival and intracellular trafficking. The PI3Ks are divided into three classes: I, II and III, and only the class I PI3Ks are involved in oncogenesis. This gene encodes the 101 kD regulatory subunit of the class I PI3K gamma complex, which is a dimeric enzyme, consisting of a 110 kD catalytic subunit gamma and a regulatory subunit of either 55, 87 or 101 kD. This protein recruits the catalytic subunit from the cytosol to the plasma membrane through high-affinity interaction with G-beta-gamma proteins. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been found. -
Synonyms
PIK3R5;phosphoinositide-3-kinase, regulatory subunit 5;phosphoinositide 3-kinase regulatory subunit 5;p101;P101 PI3K;F730038I15Rik;FOAP2;OTTHUMP00000135339;Phosphatidylinositol 4,5 bisphosphate 3 kinase regulatory subunit;Phosphoinositide 3 kinase, regulatory subunit 5;Phosphoinositide 3 kinase, regulatory subunit 5, p101;Phosphoinositide 3 kinase, regulatory subunit, polypeptide p101;PI3 kinase p101 subunit;PI3 kinase regulatory subunit 5;PIK3 R5;Protein FOAP 2;PtdIns 3 kinase p101;PtdIns 3 kinase regulatory subunit;protein FOAP-2;ptdIns-3-kinase p101;PI3-kinase p101 subunit;phosphatidylinositol-4,5-bisphosphate 3-kinase regulatory subunit;FOAP-2;P101-PI3K
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PIK3R5-2400C | Recombinant Chicken PIK3R5 | Mammalian Cells | Chicken | His |
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| PIK3R5-31760TH | Recombinant Human Human PIK3CG, His-tagged | Human | His | Full L. |
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| PIK3R5-3182HCL | Recombinant Human PIK3R5 293 Cell Lysate | HEK293 | Human | Non |
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| PIK3R5-1084H | Recombinant Human PIK3R5 Protein (1-494 aa), His-SUMO-tagged | E.coli | Human | His&SUMO | 1-494 aa |
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Involved Pathway
PIK3R5 involved in several pathways and played different roles in them. We selected most pathways PIK3R5 participated on our site, such as ErbB signaling pathway,Ras signaling pathway,Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PIK3R5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Inflammatory mediator regulation of TRP channels | PLA2G4F,BDKRB2,CAMK2B,CYP2J6,CYP2C55,HTR2A,HRH1,PIK3CD,PRKCB,ALOX12 |
| Central carbon metabolism in cancer | PGAM1,AKT2,PIK3CD,MAPK3,KRAS,G6PDX,HK3,PIK3R2,PDHA1,LDHA |
| Ras signaling pathway | KITLG,MAP2K1,PLA2G5,RGL1,FGF21,FGF19,PLA2G12B,FGF1,EFNA4,GNG11 |
| Natural killer cell mediated cytotoxicity | KLRA8,VAV3,PRF1,IFNA14,IFNA6,KLRC2,ITGB2,IFNA8,PLCG1,VAV2 |
| Apoptosis | APAF1,PTBP3,CRADD,DCC,BNIP3LB,BADB,CASP10,BIRC3,BAXB,BIRC2 |
| Fc epsilon RI signaling pathway | FYN,MAPK12,MAP2K2,GRB2,MAPK13,PRKCA,MAP2K4,MAPK11,PLCG2,PLA2G4F |
| Jak-STAT signaling pathway | IFNAR1,SOCS5,PIK3R3B,IFNA17,CRLF2,FHL1A,IL21R,HRASA,IL4R,SOCS9 |
| Toxoplasmosis | IL12B,MAPK3,PIK3R3,PDPK1,BIRC7,TGFB3,MAPK11,BCL2,MAPK13,HLA-DMA |
| Glioma | MAPK1,MTOR,NRAS,CAMK2D,PIK3CD,CALML5,SHC3,SHC4,PDGFRA,AKT2 |
Protein Function
PIK3R5 has several biochemical functions, for example, 1-phosphatidylinositol-3-kinase regulator activity,G-protein beta/gamma-subunit complex binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PIK3R5 itself. We selected most functions PIK3R5 had, and list some proteins which have the same functions with PIK3R5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| G-protein beta/gamma-subunit complex binding | GNAI2B,GNA13A,GNA13B,GNAL,GNA13,CETN4,GNAO1B,GNAT2,GNA12,GNAZ |
| 1-phosphatidylinositol-3-kinase regulator activity | PIK3R2,CCKBR,PIK3R1,PIK3R3A,PIK3R6,PIK3R3,PIK3R3B |
Interacting Protein
PIK3R5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PIK3R5 here. Most of them are supplied by our site. Hope this information will be useful for your research of PIK3R5.
PIK3CG;ADAMTS2;TTR;CXCL2;SDHB;CYP4A11;acnA
Resources
Research Area
Apoptosis Intracellular KinasesDiabetic Peripheral Neuropathy
PI 3-Kinases (Phosphoinositide 3-Kinases)
Apical-basal Polarity Effectors
Related Services
Related Products
References
- Ni, Y; Sinnett-Smith, J; et al. PKD1 Mediates Negative Feedback of PI3K/Akt Activation in Response to G Protein-Coupled Receptors. PLOS ONE 8:-(2013).
- Feola, A; Cimini, A; et al. The Inhibition of p85 alpha PI3KSer83 Phosphorylation Prevents Cell Proliferation and Invasion in Prostate Cancer Cells. JOURNAL OF CELLULAR BIOCHEMISTRY 114:2114-2119(2013).
