PIK3R3
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Official Full Name
phosphoinositide-3-kinase, regulatory subunit 3 (gamma) -
Overview
Phosphatidylinositol 3-kinase regulatory subunit gamma is an enzyme that in humans is encoded by the PIK3R3 gene. -
Synonyms
PIK3R3;phosphoinositide-3-kinase, regulatory subunit 3 (gamma);phosphatidylinositol 3-kinase regulatory subunit gamma;p55;p55PIK;PI3-kinase subunit p55-gamma;PI3K regulatory subunit gamma;100% homology to SWISS-PROT Q92569;PI3-kinase regulatory su
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- Insect Cells
- GST
- His
- Non
- His&GST
- Myc&DDK
- His&Fc&Avi
Involved Pathway
PIK3R3 involved in several pathways and played different roles in them. We selected most pathways PIK3R3 participated on our site, such as ErbB signaling pathway,Ras signaling pathway,Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PIK3R3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| AMPK signaling pathway | IRS1,ADIPOR1,CAB39,PIK3R2,STRADB,PPP2CA,SCD5,TSC2,RAB14,CPT1B |
| Non-alcoholic fatty liver disease (NAFLD) | XBP1,INS1,SDHC,PIK3R5,NDUFS5,NDUFB1,UQCR11,INS,INSR,COX4I2 |
| Insulin resistance | OGT,G6PC2,FOXO1A,PPP2R4,PYGM,INS1,PTPN11,PPP1R3CA,CD36,PTEN |
| Progesterone-mediated oocyte maturation | CDC25B,CPEB1A,GNAIA,PIK3R1,RAF1A,ANAPC11,PDE3B,MAD1L1,MAPK12B,CDH1-A |
| Small cell lung cancer | PTGS2,CASP9,RXRB,LAMA3,PIK3R2,CCNE1,TP53,NFKBIA,RARB,RXRG |
| Colorectal cancer | PIK3CG,LEF1,TGFB1,AKT1,RAC1,TGFBR1,MAPK3,BAD,DCC,MSH3 |
| Ras signaling pathway | KLK1B4,INSR,RELA,RAB5C,PIK3CA,MLLT4,FGF6,CALML3,GNG5,INS2 |
| VEGF signaling pathway | RAC2,PIK3CB,MAPK1,RAC3A,VEGFAB,PPP3CA,PIK3R2,NRAS,PIK3CA,PPP3CCB |
| Chemokine signaling pathway | CXCL8,RAP1A,CXCL1,VAV2,XCR1,CXCL13,PARD3,CCL5,RELA,GNB1 |
Protein Function
PIK3R3 has several biochemical functions, for example, 1-phosphatidylinositol-3-kinase activity,1-phosphatidylinositol-3-kinase regulator activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PIK3R3 itself. We selected most functions PIK3R3 had, and list some proteins which have the same functions with PIK3R3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | TPSAB1,THAP11,KIAA0247,CD80,KPNB1,CSE1L,PDLIM3,C5orf13,LSAMP,KISS1R |
| 1-phosphatidylinositol-3-kinase regulator activity | PIK3R6,CCKBR,PIK3R3B,PIK3R1,PIK3R2,PIK3R3A,PIK3R5 |
| 1-phosphatidylinositol-3-kinase activity | ATM,PIK3CA,PIK3CG,PIK3C2A,PIK3C3,PIK3CB,PIK3C2G,PIK3CD,PIK3C2B |
Interacting Protein
PIK3R3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PIK3R3 here. Most of them are supplied by our site. Hope this information will be useful for your research of PIK3R3.
EGFR;PIK3CA;PTK2;SRC;CRK;PLEKHS1
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