PIGA
-
Official Full Name
phosphatidylinositol glycan anchor biosynthesis, class A -
Overview
This gene encodes a protein required for synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the biosynthetic pathway of GPI anchor. The GPI anchor is a glycolipid found on many blood cells and which serves to anchor proteins to the cell surface. Paroxysmal nocturnal hemoglobinuria, an acquired hematologic disorder, has been shown to result from mutations in this gene. Alternate splice variants have been characterized. A related pseudogene is located on chromosome 12. [provided by RefSeq, Jun 2010] -
Synonyms
PIGA;phosphatidylinositol glycan anchor biosynthesis, class A;GPI3;PIG-A;MCAHS2;phosphatidylinositol N-acetylglucosaminyltransferase subunit A;GPI anchor biosynthesis;GLCNAC-PI synthesis protein;class A GlcNAc-inositol phospholipid assembly protein;phosphatidylinositol-glycan biosynthesis, class A protein
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PIGA-2506C | Recombinant Chicken PIGA | Mammalian Cell | Chicken | His |
|
|
| PIGA-3425R | Recombinant Rhesus monkey PIGA Protein, His-tagged | Mammalian Cell | Rhesus macaque | His |
|
|
| PIGA-6747Z | Recombinant Zebrafish PIGA | Mammalian Cell | Zebrafish | His |
|
|
| PIGA-3243R | Recombinant Rhesus Macaque PIGA Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
|
|
| PIGA-3243R-B | Recombinant Rhesus Macaque PIGA Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
|
||
| RFL26428HF | Recombinant Full Length Human Phosphatidylinositol N-Acetylglucosaminyltransferase Subunit A(Piga) Protein, His-Tagged | E.coli expression system | Human | His | Full L. Full Length (1-484) |
|
Involved Pathway
PIGA involved in several pathways and played different roles in them. We selected most pathways PIGA participated on our site, such as Glycosylphosphatidylinositol(GPI)-anchor biosynthesis,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with PIGA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | ETNK2,NDUFC2,GPAA1,AKR1C3,P4HA2,NOS3,ATP6AP1,KLF15,COMTB,PCYT1A |
| Glycosylphosphatidylinositol(GPI)-anchor biosynthesis | PIGF,PIGV,PIGL,PIGC,DPM2,PIGX,PIGU,PIGQ,PIGP,PIGB |
Protein Function
PIGA has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by PIGA itself. We selected most functions PIGA had, and list some proteins which have the same functions with PIGA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|
Interacting Protein
PIGA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PIGA here. Most of them are supplied by our site. Hope this information will be useful for your research of PIGA.
Resources
Related Services
Related Products
References
- Brodsky, RA; et al. Paroxysmal nocturnal hemoglobinuria. BLOOD 124:2804-2811(2014).
- Longet, S; Miled, S; et al. Human Plasma-derived Polymeric IgA and IgM Antibodies Associate with Secretory Component to Yield Biologically Active Secretory-like Antibodies. JOURNAL OF BIOLOGICAL CHEMISTRY 288:4085-4094(2013).
