PIDD
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Official Full Name
p53-induced death domain protein -
Overview
The protein encoded by this gene contains a leucine-rich repeat and a death domain. This protein has been shown to interact with other death domain proteins, such as Fas (TNFRSF6)-associated via death domain (FADD) and MAP-kinase activating death domain-containing protein (MADD), and thus may function as an adaptor protein in cell death-related signaling processes. The expression of the mouse counterpart of this gene has been found to be positively regulated by the tumor suppressor p53 and to induce cell apoptosis in response to DNA damage, which suggests a role for this gene as an effector of p53-dependent apoptosis. Alternative splicing results in multiple transcript variants. -
Synonyms
PIDD;p53-induced death domain protein;leucine rich repeats and death domain containing , LRDD;p53-induced protein with a death domain;DKFZp434D229;MGC16925;leucine-rich repeats and death domain containing;leucine-rich repeat and death domain-contai
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Involved Pathway
PIDD involved in several pathways and played different roles in them. We selected most pathways PIDD participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PIDD were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
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Protein Function
PIDD has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by PIDD itself. We selected most functions PIDD had, and list some proteins which have the same functions with PIDD. You can find most of the proteins on our site.
| Function | Related Protein |
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Interacting Protein
PIDD has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PIDD here. Most of them are supplied by our site. Hope this information will be useful for your research of PIDD.
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References
- Hernandez-Trujillo, VP; Scalchunes, C; et al. Autoimmunity and Inflammation in X-linked Agammaglobulinemia. JOURNAL OF CLINICAL IMMUNOLOGY 34:627-632(2014).
- Costa-Carvalho, BT; Grumach, AS; et al. Attending to Warning Signs of Primary Immunodeficiency Diseases Across the Range of Clinical Practice. JOURNAL OF CLINICAL IMMUNOLOGY 34:10-22(2014).
