PIAS1

  • Official Full Name

    protein inhibitor of activated STAT, 1

  • Overview

    This gene encodes a member of the mammalian PIAS (protein inhibitor of activated STAT-1 (signal transducer and;activator of transcription-1)) family. This member contains a putative zinc-binding motif and a highly acidic region.;It inhibits STAT1-mediated gene activation and the DNA binding activity, binds to Gu protein/RNA helicase II/DEAD box;polypeptide 21, and interacts with androgen receptor (AR). It functions in testis as a nuclear receptor;transcriptional coregulator and may have a role in AR initiation and maintenance of spermatogenesis.

  • Synonyms

    PIAS1;protein inhibitor of activated STAT, 1;DDXBP1, DEAD/H (Asp Glu Ala Asp/His) box binding protein 1;E3 SUMO-protein ligase PIAS1;GBP;GU/RH II;zinc finger;MIZ type containing 3;ZMIZ3;gu-binding protein;AR interacting protein;DEAD/H box-bind

Recombinant Proteins

  • Mouse
  • Human
  • Chicken
  • Rhesus macaque
  • Mammalian Cell
  • E.coli
  • HEK293
  • His
  • His&T7
  • GST
  • Non
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
PIAS1-12768M Recombinant Mouse PIAS1 Protein Mammalian Cell Mouse His
PIAS1-1865H Recombinant Human PIAS1 protein, His & T7-tagged E.coli Human His&T7 Glu409~Pro645
PIAS1-3103C Recombinant Chicken PIAS1 Mammalian Cell Chicken His
PIAS1-3421R Recombinant Rhesus monkey PIAS1 Protein, His-tagged Mammalian Cell Rhesus macaque His
PIAS1-673H Recombinant Human PIAS1, GST-tagged E.coli Human GST
PIAS1-3205HCL Recombinant Human PIAS1 293 Cell Lysate HEK293 Human Non
PIAS1-3239R Recombinant Rhesus Macaque PIAS1 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque His&Fc&Avi
PIAS1-3239R-B Recombinant Rhesus Macaque PIAS1 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
PIAS1-6718M Recombinant Mouse PIAS1 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
PIAS1-6718M-B Recombinant Mouse PIAS1 Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    PIAS1 involved in several pathways and played different roles in them. We selected most pathways PIAS1 participated on our site, such as Ubiquitin mediated proteolysis,Jak-STAT signaling pathway,Hepatitis C, which may be useful for your reference. Also, other proteins which involved in the same pathway with PIAS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Hepatitis C CLDN18,HRAS,TNF,PDPK1,CXCL8,EIF2AK4,PPP2R2B,CLDN2,MAPK11,MAPK8
    Ubiquitin mediated proteolysis UBE2E3,UBE2KB,SOCS1A,SMURF2,TCEB1B,UBR5,CDC34,CDC16,CDH1-A,UBE4A
    Jak-STAT signaling pathway FHL1,IL15,IFNA6,AOX4,IFNG1-2,IL24,IFNA7,AKT2,PIK3R1,IL7R

    Protein Function

    PIAS1 has several biochemical functions, for example, DNA binding,SUMO ligase activity,androgen receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PIAS1 itself. We selected most functions PIAS1 had, and list some proteins which have the same functions with PIAS1. You can find most of the proteins on our site.

    Function Related Protein
    androgen receptor binding KDM4C,BRCA1,PRKCBB,TGFB1I1,DDX5,CDK7,NCOA1,PIAS2,KDM1A,TCF21
    protein binding RNF111,NCOA2,FGF7,KDM5B,RB1,ISYNA1,MSX2,CREB3L3,APOBEC3H,PTI
    zinc ion binding PRICKLE1,ZCCHC7,NR2F1,NR2F1B,QPCT,FTR54,RNF182,RNF207,ADAM22,LHX3
    ubiquitin protein ligase binding TMBIM6,TRAF1,NAE1,RFFL,NDUFS2,STX8,JAK1,SUMO2,BCL2,HSPA1A
    DNA binding CEBPA,IRF1,NR1I3,GATA4,HOXA13B,RAD51L3,NFYAL,ASCL5,IMPDH2,UBN2A
    transcription corepressor activity WNT4,MTA1,PBXIP1,TGIF1,ATF7IP,NR1H4,NAB2,ZNF593,E2F6,TRIB3
    SUMO ligase activity PIAS2,PIAS4
    ligase activity ITCH,RNF216,NAPRT1,SIAH2,ZNRF2,GATB,RNF125,MARCH5L,RNF6,RNF144AB
    enzyme binding NPM2,PDE4D,CUTA,HDAC6,CYP2A6,PPP3CB,TP53,MDM2,NOXA1,CRB2

    Interacting Protein

    PIAS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PIAS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PIAS1.

    TP53;MBD1;SMAD4;PRDM1;CASP8AP2;PASK;PIAS2;E1;E1;PTPN1

    PIAS1 Related Signal Pathway

    Resources

    References

    • Ying, HY; Su, ST; et al. SUMOylation of Blimp-1 is critical for plasma cell differentiation. EMBO REPORTS 13:631-637(2012).

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