PHOX2A
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Official Full Name
paired-like homeobox 2a -
Overview
The protein encoded by this gene contains a paired-like homeodomain most similar to that of the Drosophila aristaless gene product. The encoded protein plays a central role in development of the autonomic nervous system. It regulates the expression of tyrosine hydroxylase and dopamine beta-hydroxylase, two catecholaminergic biosynthetic enzymes essential for the differentiation and maintenance of the noradrenergic neurotransmitter phenotype. The encoded protein has also been shown to regulate transcription of the alpha3 nicotinic acetylcholine receptor gene. Mutations in this gene have been associated with autosomal recessive congenital fibrosis of the extraocular muscles. -
Synonyms
PHOX2A;paired-like homeobox 2a;aristaless (Drosophila) homeobox, aristaless homeobox (Drosophila), fibrosis of extraocular muscles, congenital, 2, autosomal recessive , ARIX, FEOM2, paired like (aristaless) homeobox 2a;paired mesoderm homeobox protein 2A;CFEOM2;PMX2A;Aristaless homeobox (Drosophila) fibrosis of extraocular muscles congenital 2 autosomal recessive;Aristaless homeobox gene homolog (Drosophila);Aristaless homeobox homolog;Aristaless homeobox protein homolog;ARIX 1 homeodomain protein;ARIX;Arix homeodomain protein;ARIX1 homeodomain protein;CFEOM 2;FEOM 2;FEOM2;Fibrosis of extraocular muscles congenital 2 autosomal recessive;MGC52227;NCAM 2;NCAM2;Paired like (aristaless) Homeobox 2A;Paired like homeobox 2a;Paired mesoderm homeobox 2a;PHOX 2A;Phox2;PHX2A_HUMAN;Pmx 2a;Pmx2;OTTHUMP00000237214
Recombinant Proteins
- Zebrafish
- Mouse
- Rat
- Human
- Mammalian Cell
- HEK293
- His
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PHOX2A-11802Z | Recombinant Zebrafish PHOX2A | Mammalian Cell | Zebrafish | His |
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| PHOX2A-12751M | Recombinant Mouse PHOX2A Protein | Mammalian Cell | Mouse | His |
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| PHOX2A-4431R | Recombinant Rat PHOX2A Protein | Mammalian Cell | Rat | His |
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| PHOX2A-614H | Recombinant Human PHOX2A | Mammalian Cell | Human | His |
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| PHOX2A-1347HCL | Recombinant Human PHOX2A cell lysate | Human | Non |
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| PHOX2A-3850H | Recombinant Human PHOX2A Protein, His (Fc)-Avi-tagged | HEK293 | Human | His&Fc&Avi |
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| PHOX2A-3850H-B | Recombinant Human PHOX2A Protein Pre-coupled Magnetic Beads | HEK293 | Human |
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| PHOX2A-4091R | Recombinant Rat PHOX2A Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| PHOX2A-4091R-B | Recombinant Rat PHOX2A Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| PHOX2A-6709M | Recombinant Mouse PHOX2A Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| PHOX2A-6709M-B | Recombinant Mouse PHOX2A Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
PHOX2A involved in several pathways and played different roles in them. We selected most pathways PHOX2A participated on our site, such as SIDS Susceptibility Pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with PHOX2A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| SIDS Susceptibility Pathways | PLP1,GATA2,POU2F2,EN1,CHRFAM7A,TPH2,CTCF,POU3F2,ECE1,TSPYL1 |
Protein Function
PHOX2A has several biochemical functions, for example, RNA polymerase II regulatory region sequence-specific DNA binding,transcription factor activity, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PHOX2A itself. We selected most functions PHOX2A had, and list some proteins which have the same functions with PHOX2A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription factor activity, sequence-specific DNA binding | CITED1,FOXN4,CITED2,FOXA2,TFCP2L1,HIF1AB,CNOT7,TSC22D2,SOX21,ZNF711 |
| RNA polymerase II regulatory region sequence-specific DNA binding | MNT,ZFP39,FOXD3,GATA6,ZNF792,ATF2,NFKB1,GATA3,E2F7,BARX1 |
Interacting Protein
PHOX2A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PHOX2A here. Most of them are supplied by our site. Hope this information will be useful for your research of PHOX2A.
Resources
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References
- Shin, MH; Mavila, N; et al. Time-Dependent Activation of Phox2a by the Cyclic AMP Pathway Modulates Onset and Duration of p27(Kip1) Transcription. MOLECULAR AND CELLULAR BIOLOGY 29:4878-4890(2009).
- Benjanirut, C; Paris, M; et al. The cAMP pathway in combination with BMP2 regulates Phox2a transcription via cAMP response element binding sites. JOURNAL OF BIOLOGICAL CHEMISTRY 281:2969-2981(2006).
