PHKB
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Official Full Name
phosphorylase kinase, beta -
Overview
Phosphorylase kinase is a polymer of 16 subunits, four each of alpha, beta, gamma and delta. The alpha subunit includes the skeletal muscle and hepatic isoforms, encoded by two different genes. The beta subunit is the same in both the muscle and hepatic isoforms, encoded by this gene, which is a member of the phosphorylase b kinase regulatory subunit family. The gamma subunit also includes the skeletal muscle and hepatic isoforms, encoded by two different genes. The delta subunit is a calmodulin and can be encoded by three different genes. The gamma subunits contain the active site of the enzyme, whereas the alpha and beta subunits have regulatory functions controlled by phosphorylation. The delta subunit mediates the dependence of the enzyme on calcium concentration. Mutations in this gene cause glycogen storage disease type 9B, also known as phosphorylase kinase deficiency of liver and muscle. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. Two pseudogenes have been found on chromosomes 14 and 20, respectively. -
Synonyms
PHKB;phosphorylase kinase, beta;phosphorylase b kinase regulatory subunit beta;DKFZp781E15103;FLJ41698;Phosphorylase kinase B;Phosphorylase kinase beta polypeptide;Phosphorylase kinase beta subunit;OTTHUMP00000164134;phosphorylase kinase beta-subunit;phosphorylase kinase subunit beta
Recombinant Proteins
- Mouse
- Chicken
- Rhesus macaque
- Human
- Mammalian Cell
- HEK293T
- HEK293
- His
- Myc&DDK
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PHKB-12739M | Recombinant Mouse PHKB Protein | Mammalian Cell | Mouse | His |
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| PHKB-1757C | Recombinant Chicken PHKB | Mammalian Cell | Chicken | His |
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| PHKB-3411R | Recombinant Rhesus monkey PHKB Protein, His-tagged | Mammalian Cell | Rhesus macaque | His |
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| Phkb-200M | Recombinant Mouse Phkb Protein, MYC/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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| PHKB-3229R | Recombinant Rhesus Macaque PHKB Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| PHKB-3229R-B | Recombinant Rhesus Macaque PHKB Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| PHKB-3423H | Recombinant Human PHKB Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
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| PHKB-6699M | Recombinant Mouse PHKB Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| PHKB-6699M-B | Recombinant Mouse PHKB Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
PHKB involved in several pathways and played different roles in them. We selected most pathways PHKB participated on our site, such as Calcium signaling pathway,Insulin signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PHKB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Insulin signaling pathway | SOCS1A,SH2B2,SOCS4,RPS6,KRAS,FOXO1,PPP1R3D,PPP1R3CB,TSC2,PPP1CAB |
| Calcium signaling pathway | ADRB2,CAMK2G,CACNA1D,STIM1A,GRIN2A,ADORA2AB,PHKA2,CACNA1DA,DRD1A,PTGER1 |
Protein Function
PHKB has several biochemical functions, for example, calmodulin binding,catalytic activity,contributes_to phosphorylase kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PHKB itself. We selected most functions PHKB had, and list some proteins which have the same functions with PHKB. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calmodulin binding | MYH9,PLA2G6,TRPV5,CAMK2D,AKAP5,IQCB1,ITPKB,MYLK,MARCKSL1,MKNK2 |
| phosphorylase kinase activity | PHKG1,PHKG1B,PHKG1A,PHKG2,PHKA2 |
| catalytic activity | SPTLC2B,PNP6,RSAD2,HADHAB,ALDH1L1,TM9SF1,FH1,PPTC7A,GULO,HADHAA |
| contributes_to phosphorylase kinase activity | PHKA1 |
Interacting Protein
PHKB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PHKB here. Most of them are supplied by our site. Hope this information will be useful for your research of PHKB.
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References
- de Luna, N; Brull, A; et al. PYGM expression analysis in white blood cells: A complementary tool for diagnosing McArdle disease?. NEUROMUSCULAR DISORDERS 24:1079-1086(2014).
- Ammendola, M; Sacco, R; et al. Correlation between Serum Tryptase, Mast Cells Positive to Tryptase and Microvascular Density in Colo-Rectal Cancer Patients: Possible Biological-Clinical Significance. PLOS ONE 9:-(2014).
