PHIP
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Official Full Name
pleckstrin homology domain interacting protein -
Overview
PHIP binds the pleckstrin homology (PH) domain of insulin receptor substrate-1 (IRS1; MIM 147545), modulates insulin;signaling, and plays a role in pancreatic beta cell growth and survival (Farhang-Fallah et al., 2000 (PubMed;11018022); Podcheko et al., 2007 (PubMed 17636024)). -
Synonyms
PHIP;pleckstrin homology domain interacting protein;WDR11;PH-interacting protein;BRWD2;DCAF14;DDB1 and CUL4 associated factor 14;FLJ20705;ndrp;IRS-1 PH domain-binding protein;WD repeat-containing protein 11;FLJ45918;MGC90216
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PHIP-1683H | Recombinant Human PHIP, His-tagged | E.coli | Human | His | C-350aa | |
| PHIP-169H | Recombinant Human PHIP Protein, GST-tagged | E.coli | Human | GST | 1302-1434 |
|
| PHIP-170H | Recombinant Human PHIP Protein, His-tagged | E.coli | Human | His | 1302-1434 |
|
| PHIP-171H | Recombinant Human PHIP Protein, GST-tagged | E.coli | Human | GST | 1141-1434 |
|
| PHIP-64H | Recombinant Human PHIP, His&FLAG-tagged | E.coli | Human | His&Flag | 1302-1434 a.a. |
|
Involved Pathway
PHIP involved in several pathways and played different roles in them. We selected most pathways PHIP participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PHIP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
PHIP has several biochemical functions, for example, insulin receptor binding,lysine-acetylated histone binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PHIP itself. We selected most functions PHIP had, and list some proteins which have the same functions with PHIP. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| lysine-acetylated histone binding | TAF1L,BRD7,ATAD2B,TRIM24,MLL1,BRDT,BAZ2A,TAF1,PSME4,SMARCA4 |
| insulin receptor binding | INS1,FRS2B,SHC1,IGF1R,LMBRD1,SNX4,PTPN1,IRS4,INS2,DOK4 |
| protein binding | TAB2,TRPM6,FKBP5,MAP3K1,DVL2,POLR2J,Trl,CDX4,CST9L,ZFP64 |
Interacting Protein
PHIP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PHIP here. Most of them are supplied by our site. Hope this information will be useful for your research of PHIP.
NR4A1;TUBB4A;tkt1;STMN4;Brwd3;EGR1;RPL10;TMPO;Eif3e;Cbx1;ORC1;CUL4B;IFI16;Cul4a;Atrx;PYHIN1;HDAC11;MPHOSPH8;Chaf1a
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References
- Szterk, A; et al. Chemical state of heterocyclic aromatic amines in grilled beef: Evaluation by in vitro digestion model and comparison of alkaline hydrolysis and organic solvent for extraction. FOOD AND CHEMICAL TOXICOLOGY 62:653-660(2013).
- Larman, HB; Laserson, U; et al. PhIP-Seq characterization of autoantibodies from patients with multiple sclerosis, type 1 diabetes and rheumatoid arthritis. JOURNAL OF AUTOIMMUNITY 43:1-9(2013).
