PHF5A
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Official Full Name
PHD finger protein 5A -
Overview
This gene encodes a subunit of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the introns branch site in a sequence-independent manner and may anchor the U2 snRNP to the pre-mRNA. The protein encoded by this gene contains a PHD-finger-like domain that is flanked by highly basic N- and C-termini. This protein belongs to the PHD-finger superfamily and may act as a chromatin-associated protein. This gene has several pseudogenes on different chromosomes. -
Synonyms
PHF5A;PHD finger protein 5A;PHD finger-like domain-containing protein 5A;bK223H9.2;INI;MGC1346;Rds3;SAP14b;SF3b14b;PHD finger like domain containing protein 5A;1110007B08Rik;Ac2 246;OTTHUMP00000198827;PHD finger 5a;PHD finger like domain protein 5A;PHD finger-like domain protein 5A;PHF5A_HUMAN;Splicing factor 3B associated 14 kDa protein;Splicing factor 3B-associated 14 kDa protein;Transcription factor INI;PHD-finger 5a
Recombinant Proteins
- Human
- Mouse
- Chicken
- Zebrafish
- E.coli
- Mammalian Cell
- HEK293
- GST
- His
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PHF5A-1681H | Recombinant Human PHF5A, GST-tagged | E.coli | Human | GST | 1-110aa | |
| PHF5A-12730M | Recombinant Mouse PHF5A Protein | Mammalian Cell | Mouse | His |
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| PHF5A-213H | Recombinant Human PHD finger protein 5A, His-tagged | E.coli | Human | His | 1-110 a.a. |
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| PHF5A-4790C | Recombinant Chicken PHF5A | Mammalian Cell | Chicken | His |
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| PHF5A-9538Z | Recombinant Zebrafish PHF5A | Mammalian Cell | Zebrafish | His |
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| PHF5A-3226HCL | Recombinant Human PHF5A 293 Cell Lysate | HEK293 | Human | Non |
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| PHF5A-6693M | Recombinant Mouse PHF5A Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| PHF5A-6693M-B | Recombinant Mouse PHF5A Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
PHF5A involved in several pathways and played different roles in them. We selected most pathways PHF5A participated on our site, such as Spliceosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with PHF5A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Spliceosome | HSPA1B,PRPF40B,SRSF1,RBM25,HNRNPA1,LSM3,THOC3,PRPF19,CWC15,SRSF9 |
Protein Function
PHF5A has several biochemical functions, for example, DNA binding,poly(A) RNA binding,transcription factor activity, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PHF5A itself. We selected most functions PHF5A had, and list some proteins which have the same functions with PHF5A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | SFPI1,KLF5,PATZ1,ZNF484,NFATC2,FOXJ1B,HOXB3A,ASXL3,ZFP524,ZFP143 |
| transcription factor activity, sequence-specific DNA binding | NR3C2,THRB,CREB5,SMAD3,RUNX1,HOMEZ,KDM5A,TBX5B,PRDM2,ETS2 |
| poly(A) RNA binding | MSI2,EPPK1,SRSF7,PPAN,PSMD4,HMGB3,DIAPH1,SUPV3L1,RPS4X,RBM5 |
Interacting Protein
PHF5A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PHF5A here. Most of them are supplied by our site. Hope this information will be useful for your research of PHF5A.
SF3A2;Sf3a1;ZDHHC17;PRPF31;FOXB1;ssrna_ag;PTBP3;Lck;PPP3CB;VCAM1;EMC2;CHST15;AGO1;SRPK3
Resources
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References
- Falck, E; Klinga-Levan, K; et al. Expression patterns of Phf5a/PHF5A and Gja1/GJA1 in rat and human endometrial cancer. CANCER CELL INTERNATIONAL 13:-(2013).
- Zhang, CC; He, L; et al. Screening of cellular proteins that interact with the classical swine fever virus non-structural protein 5A by yeast two-hybrid analysis. JOURNAL OF BIOSCIENCES 39:63-74(2014).
