PHF21A
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Official Full Name
PHD finger protein 21A -
Overview
The PHF21A gene encodes BHC80, a component of a BRAF35 (MIM 605535)/histone deacetylase (HDAC; see MIM 601241) complex (BHC) that mediates repression of neuron-specific genes through the cis-regulatory element known as repressor element-1 (RE1) or neural restrictive silencer (NRS) (Hakimi et al., 2002 [PubMed 12032298]).[supplied by OMIM, Nov 2010] -
Synonyms
PHF21A;PHD finger protein 21A;BHC80;BM-006;BHC80a;BRAF35/HDAC2 complex (80 kDa);BRAF35-HDAC complex protein BHC80
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PHF21A-3407R | Recombinant Rhesus monkey PHF21A Protein, His-tagged | Mammalian Cell | Rhesus macaque | His |
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| PHF21A-4440C | Recombinant Chicken PHF21A | Mammalian Cell | Chicken | His |
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| PHF21A-3230HCL | Recombinant Human PHF21A 293 Cell Lysate | HEK293 | Human | Non |
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| PHF21A-3225R | Recombinant Rhesus Macaque PHF21A Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| PHF21A-3225R-B | Recombinant Rhesus Macaque PHF21A Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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Involved Pathway
PHF21A involved in several pathways and played different roles in them. We selected most pathways PHF21A participated on our site, such as Chromatin modifying enzymes,Chromatin organization,Factors involved in megakaryocyte development and platelet production, which may be useful for your reference. Also, other proteins which involved in the same pathway with PHF21A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| HDACs deacetylate histones | CHD4,MTA2,SUDS3,GATAD2A,GATAD2B,MTA3,SAP30,GATAD2AB,ARID4A,SAP18 |
| Hemostasis | KIF22,KCNMB1,APOER2,KIF3C,GRB7,SIRPA,PDPN,ABHD6B,KCNMB2,VPS45 |
| Factors involved in megakaryocyte development and platelet production | KIF3C,AKAP1B,BA1,GATA1,HMG20B,HBB-Y,KIF15,KIF22,GATA1A,BA2 |
| Chromatin modifying enzymes | SUZ12A,PBRM1L,JHDM1D,SMARCC2,ING4,ANO9A,VPS72,CHD4,ARID5B,KDM4D |
| Chromatin organization | SMARCC2,ING5A,KDM6B,KDM1B,BRPF1,BRD8,BRPF3,VPS72,MTA2,EHMT2 |
Protein Function
PHF21A has several biochemical functions, for example, RNA polymerase II regulatory region sequence-specific DNA binding,chromatin binding,histone binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PHF21A itself. We selected most functions PHF21A had, and list some proteins which have the same functions with PHF21A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | SMAD1,LNX1,DKC1,BATF2,ATP6V1C2,LILRB4,MED25,KIAA1191,DEFA6,NOS3 |
| transcription cofactor activity | MAP3K7,ZNF710A,SUPT20H,ZFP865,MED30,ELK4,TMF1,ZFP667,HES6,MAX |
| zinc ion binding | BTR29,RNF31,TRIM35-23,CPN1,ZDHHC14,RBM4,ZMYM5,SNRPC,MT2,NR1D4A |
| chromatin binding | JUN,NR5A5,HDAC7,PLAC8,NKX2-5,TRIM24,CCDC111,TOP2B,PRMT6,PPARG |
| RNA polymerase II regulatory region sequence-specific DNA binding | ATF1,RELA,PRDM12B,STAT4,ZSCAN2,ZNF8,SATB1,XBP1,ZNF548,OSR2 |
| histone binding | DEK,MYSM1,ATAD2,H2AFX,HIST1H4F,BAZ2A,RCC1,DNAJC2,HIST1H4D,MCM2 |
Interacting Protein
PHF21A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PHF21A here. Most of them are supplied by our site. Hope this information will be useful for your research of PHF21A.
NUP62;TRAF1;FHL3;ZYX;KRT40;BANP;HDAC2
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References
- Montgomery, ND; Turcott, CM; et al. A 137-kb deletion within the Potocki-Shaffer syndrome interval on chromosome 11p11.2 associated with developmental delay and hypotonia. AMERICAN JOURNAL OF MEDICAL GENETICS PART A 161A:198-202(2013).
- Kim, HG; Kim, HT; et al. Translocations Disrupting PHF21A in the Potocki-Shaffer-Syndrome Region Are Associated with Intellectual Disability and Craniofacial Anomalies. AMERICAN JOURNAL OF HUMAN GENETICS 91:56-72(2012).
