PFKL
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Official Full Name
phosphofructokinase, liver -
Overview
Phosphofructokinase (PFK) catalyzes the phosphorylation of fructose-6-phosphate in glycolysis. There are three isozymes: muscle-type, liver-type, and platelet-type. The liver-type PFK (PFKL) is the predominant subunit of PFK found in the liver . Research -
Synonyms
PFKL;phosphofructokinase, liver;6-phosphofructokinase, liver type;phosphohexokinase;phosphofructokinase 1;liver-type 1-phosphofructokinase;phosphofructo-1-kinase isozyme B;PFK-B;FLJ30173;FLJ40909;DKFZp686G1648;DKFZp686L2097
Recombinant Proteins
- Human
- Mouse
- Rat
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- GST
- His
- His&T7
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PFKL-1657H | Recombinant Human PFKL, GST-tagged | E.coli | Human | GST | 424-780aa | |
| PFKL-12664M | Recombinant Mouse PFKL Protein | Mammalian Cell | Mouse | His |
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| PFKL-1658H | Recombinant Human PFKL protein, GST-tagged | Wheat Germ | Human | GST | 1 a.a. - 827 a.a. |
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| PFKL-4394R | Recombinant Rat PFKL Protein | Mammalian Cell | Rat | His |
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| Pfkl-8012R | Recombinant Rat Pfkl protein, His & T7-tagged | E.coli | Rat | His&T7 | Ala2~His390 |
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| PFKL-3272HCL | Recombinant Human PFKL 293 Cell Lysate | HEK293 | Human | Non |
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| PFKL-3273HCL | Recombinant Human PFKL 293 Cell Lysate | HEK293 | Human | Non |
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| PFKL-2581H | Recombinant Human PFKL Protein, His-tagged | E.coli | Human | His | Ala2-His390 |
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| PFKL-4054R | Recombinant Rat PFKL Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| PFKL-4054R-B | Recombinant Rat PFKL Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| PFKL-568HF | Recombinant Full Length Human PFKL Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 827 amino acids |
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| PFKL-6653M | Recombinant Mouse PFKL Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| PFKL-6653M-B | Recombinant Mouse PFKL Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
PFKL involved in several pathways and played different roles in them. We selected most pathways PFKL participated on our site, such as Glycolysis / Gluconeogenesis,Pentose phosphate pathway,Fructose and mannose metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with PFKL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Central carbon metabolism in cancer | MAPK1,TRP53,MAP2K2,MET,SLC1A5,PKM,PIK3R5,ERBB2,SCO2,PIK3R2 |
| Glycolysis / Gluconeogenesis | PGK2,ADH7,ALDOCA,ALDH3A1,ALDH1A3,TPI1,ADH4,LDHBA,GM5506,ACSS2 |
| HIF- signaling pathway | CAMK2B,PLCG1,IGF1R,TLR4,EIF4E1B,INS,Il6ra,PIK3CA,HK3,ENO3 |
| Metabolic pathways | COX7B2,DHRS4L2,SORD,NDUFA4L,IDO1,CMPK1,LIPG,NT5C1B-RDH14,PLD4,ST6GALNAC5 |
| RNA degradation | DDX6,TOB1,CNOT8,BTG1,PABPC4,DHX36,CNOT6L,CNOT4,TOB1A,GM5506 |
| AMPK signaling pathway | Scd1,AKT2,ADIPOR1,PPP2CA,ELAVL1,CREB3L3,IGF1R,CCNA2,PPP2R2B,CCNA1 |
| Fructose and mannose metabolism | DHRS13L1,PMM2,PFKM,AKR1B10,ALDOAB,HK3,PFKFB2A,GMDS,KHK,ENOSF1 |
| Biosynthesis of amino acids | GPT2L,ENO3,GAPDH,SHMT1,CBS,RPE,GOT2,ENO1A,ALDH7A1,IDH3G |
| Pentose phosphate pathway | TALDO1,PFKM,deoC,G6PDX,PFKMB,PGLS,ALDOAB,DERA,PRPS2,FBP1A |
Protein Function
PFKL has several biochemical functions, for example, 6-phosphofructokinase activity,contributes_to 6-phosphofructokinase activity,ATP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PFKL itself. We selected most functions PFKL had, and list some proteins which have the same functions with PFKL. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| fructose binding | PFKM,ALDOB,ALDOA |
| metal ion binding | PVALB9,BMPR2,SNAI1,KLF1,ACVR2A,ASXL3,ZNF362A,PNLIP,HBBE3,TRIM108 |
| protein binding | TUBB4A,RAB43,PICALM,MED25,SHC1,ZNF136,DIS3L,RNF180,RPS3,BCL2L16 |
| ATP binding | ATP13A1,ABCG4B,NIM1,FYNA,DMC1,EPHA5,CAMK2B,VPS4A,NLRC4,ATP2B2 |
| kinase binding | CHP1,GFAP,PIP5K1A,BCL10,STUB1,SRC,MOB4,PARP16,TRIP6,RB1 |
| fructose-6-phosphate binding | PFKFB1,GCKR |
| identical protein binding | TP63,ATXN10,ALDOA,CBX3,C10orf88,TRIM8,PLN,LECT2,S100A4,PARK2 |
| 6-phosphofructokinase activity | PFKMA,PFKM,PFKLB,PFKMB,PFKP |
Interacting Protein
PFKL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PFKL here. Most of them are supplied by our site. Hope this information will be useful for your research of PFKL.
PFKM;KRTAP5-9;KRTAP10-7;GTPBP3;1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate
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References
- Shin, JH; Krapfenbauer, K; et al. Mass-spectrometrical analysis of proteins encoded on chromosome 21 in human fetal brain. AMINO ACIDS 31:435-447(2006).
- Peled-Kamar, M; Degani, H; et al. Altered brain glucose metabolism in transgenic-PFKL mice with elevated L-phosphofructokinase: in vivo NMR studies. BRAIN RESEARCH 810:138-145(1998).
