PFAS
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Official Full Name
phosphoribosylformylglycinamidine synthase -
Overview
Purines are necessary for many cellular processes, including DNA replication, transcription, and energy metabolism. Ten enzymatic steps are required to synthesize inosine monophosphate (IMP) in the de novo pathway of purine biosynthesis. The enzyme encoded by this gene catalyzes the fourth step of IMP biosynthesis. -
Synonyms
PFAS;phosphoribosylformylglycinamidine synthase;FGAR amidotransferase;FGARAT;KIAA0361;PURL;FGAM synthase;formylglycinamide ribotide synthetase;formylglycinamide ribotide amidotransferase;FGAMS
Recombinant Proteins
- Zebrafish
- Human
- Mouse
- Mammalian Cell
- HEK293
- E.coli
- Mammalian cells
- HEK293T
- His
- His&Fc&Avi
- His&Myc&SUMO
- Flag
- Myc&DDK
Involved Pathway
PFAS involved in several pathways and played different roles in them. We selected most pathways PFAS participated on our site, such as Purine metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with PFAS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | PRIM2,PDHA2,ACSS2,EPT1,NDUFA7,HMGCL,CSGALNACT1,XDH,CYP2C37,GSTZ1 |
| Purine metabolism | POLE3,ITPA,GC2,POLR2J2,ATIC,PDE6A,PAPSS2A,POLR3A,NME5,DGUOK |
Protein Function
PFAS has several biochemical functions, for example, ATP binding,metal ion binding,phosphoribosylformylglycinamidine synthase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PFAS itself. We selected most functions PFAS had, and list some proteins which have the same functions with PFAS. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | DDX28,TSSK2,TLK1A,PC,ERBB3A,EPHA4B,CDC34,PRKG1,CSNK2A2A,ABCC8 |
| metal ion binding | RNF222,PRKAA2,HGS,ZBTB49,ELAC2,ZNF740B,FCN1,CAR15,PMELA,OGDH |
Interacting Protein
PFAS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PFAS here. Most of them are supplied by our site. Hope this information will be useful for your research of PFAS.
Resources
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References
- Webster, GM; Venners, SA; et al. Associations between Perfluoroalkyl acids (PFASs) and maternal thyroid hormones in early pregnancy: A population-based cohort study. ENVIRONMENTAL RESEARCH 133:338-347(2014).
- Granum, B; Haug, LS; et al. Pre-natal exposure to perfluoroalkyl substances may be associated with altered vaccine antibody levels and immune-related health outcomes in early childhood. JOURNAL OF IMMUNOTOXICOLOGY 10:373-379(2013).
