PEX2
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Official Full Name
peroxisomal biogenesis factor 2 -
Overview
This gene encodes an integral peroxisomal membrane protein required for peroxisome biogenesis. The protein is thought to be involved in peroxisomal matrix protein import. Mutations in this gene result in one form of Zellweger syndrome and infantile Refsum disease. Alternative splicing results in multiple transcript variants encoding the same protein. -
Synonyms
PEX2;peroxisomal biogenesis factor 2;peroxisomal membrane protein 3 (35kD, Zellweger syndrome) , peroxisomal membrane protein 3, 35kDa , PXMP3;PAF 1;peroxin 2;PMP35;RNF72;Zellweger syndrome;ZWS3;35 kDa peroxisomal membrane protein;PAF-1;PAF1;Peroxin-2;Peroxisomal membrane protein 3;peroxisomal membrane protein 3, 35kDa;Peroxisome assembly factor 1;Peroxisome biogenesis factor 2;PEX2_HUMAN;PMP3;PXMP3;RING finger protein 72;OTTHUMP00000226907;OTTHUMP00000226908;OTTHUMP00000226909;OTTHUMP00000226911;peroxisome assembly factor-1
Recombinant Proteins
- Mouse
- Chicken
- Human
- Rat
- Yarrowia lipolytica
- Podospora anserina (Pleurage anserina)
- Dictyostelium Discoideum
- Mus musculus
- Komagataella pastoris (Yeast) (Pichia pastoris)
- Mammalian Cell
- E.coli
- HEK293
- E.coli expression system
- His
- His&T7
- Non
- His&Fc&Avi
Involved Pathway
PEX2 involved in several pathways and played different roles in them. We selected most pathways PEX2 participated on our site, such as Peroxisome, which may be useful for your reference. Also, other proteins which involved in the same pathway with PEX2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Peroxisome | CRATA,PRDX5,HSD17B4,NOS2B,PEX5,PIPOX,ACSL3A,PAOX,HAO2,IDH1 |
Protein Function
PEX2 has several biochemical functions, for example, protein binding,ubiquitin-protein transferase activity,zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PEX2 itself. We selected most functions PEX2 had, and list some proteins which have the same functions with PEX2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| zinc ion binding | TRIM41,CHD4,TEX13A,MMP26,TRIM35-23,TRIM2A,ZDHHC18B,HNF4G,NUP153,ZSWIM4 |
| protein binding | CRHBP,RNF11,GYPC,MIER1,FAM156A,STX18,C21orf7,RWDD3,NKX2-1,ITGB5 |
| ubiquitin-protein transferase activity | ZNRF1,FEM1B,RNF41,PDZRN3B,MYCBP2,UHRF1,HACE1,SMURF2,TRIM33,ZYG11 |
Interacting Protein
PEX2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PEX2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PEX2.
PEX19;TLE1;cirA2;C14orf1;cdkn1a_human_gene;PEX14;UBE2A;UBE2B;PEX5
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References
- Carrero-Lerida, J; Perez-Moreno, G; et al. Intracellular location of the early steps of the isoprenoid biosynthetic pathway in the trypanosomatids Leishmania major and Trypanosoma brucei. INTERNATIONAL JOURNAL FOR PARASITOLOGY 39:307-314(2009).
- Shimozawa, N; Zhang, ZY; et al. Molecular mechanism of detectable catalase-containing particles, peroxisomes, in fibroblasts from a PEX2-defective patient. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 268:31-35(2000).
