PEX1
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Official Full Name
peroxisomal biogenesis factor 1 -
Overview
This gene encodes a member of the AAA ATPase family, a large group of ATPases associated with diverse cellular activities. This protein is cytoplasmic but is often anchored to a peroxisomal membrane where it forms a heteromeric complex and plays a role in the import of proteins into peroxisomes and peroxisome biogenesis. Mutations in this gene have been associated with complementation group 1 peroxisomal disorders such as neonatal adrenoleukodystrophy, infantile Refsum disease, and Zellweger syndrome. -
Synonyms
PEX1;peroxisomal biogenesis factor 1;peroxisome biogenesis factor 1 , Zellweger syndrome , Zellweger syndrome 1 , ZWS, ZWS1;peroxisome biogenesis factor 1;Highly similar to ATPase [H.sapiens];Peroxin 1;Peroxin-1;peroxin1;Peroxisome biogenesis disorder protein 1;PEX1_HUMAN;ZWS1;Zellweger syndrome;ZWS
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- E.coli
- Mammalian Cell
- HEK293
- His
- His&T7
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PEX1-1648H | Recombinant Human PEX1, His-tagged | E.coli | Human | His | C-term-357aa | |
| PEX1-577H | Recombinant Human PEX1 | Mammalian Cell | Human | His |
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| PEX1-7654Z | Recombinant Zebrafish PEX1 | Mammalian Cell | Zebrafish | His |
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| Pex1-8029M | Recombinant Mouse Pex1 protein, His & T7-tagged | E.coli | Mouse | His&T7 | Asn172~Ala377 |
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| PEX1-1335HCL | Recombinant Human PEX1 cell lysate | Human | Non |
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| PEX1-3828H | Recombinant Human PEX1 Protein, His (Fc)-Avi-tagged | HEK293 | Human | His&Fc&Avi |
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| PEX1-3828H-B | Recombinant Human PEX1 Protein Pre-coupled Magnetic Beads | HEK293 | Human |
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| PEX1-4864H | Recombinant Human PEX1 Protein (Glu62-Gln219), N-His tagged | E.coli | Human | His | Glu62-Gln219 |
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Involved Pathway
PEX1 involved in several pathways and played different roles in them. We selected most pathways PEX1 participated on our site, such as Peroxisome, which may be useful for your reference. Also, other proteins which involved in the same pathway with PEX1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Peroxisome | ANI_1_2390104,MPV17L2,ECI2,DAO.2,PEX11C,SCP2A,SLC25A17,HAO2,DECR2,EPHX2 |
Protein Function
PEX1 has several biochemical functions, for example, ATP binding,ATPase activity, coupled,protein C-terminus binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PEX1 itself. We selected most functions PEX1 had, and list some proteins which have the same functions with PEX1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | CDK14,ASS1,P2RX5,CAMKK2,TTLL5,TSSK6,DYRK1B,EPHA2,SLC22A5,CDK4 |
| protein C-terminus binding | PEX5,TOP2A,SNTG1,MIF4GD,TERF2,VPS4A,BLOC1S2,PEX16,BCAM,SIRT1 |
| protein complex binding | MLKL,ATF1,BAG3,AP2A1,TXN2,PRKACA,NOG,RAD18,FGFR1,SHARPIN |
| ATPase activity, coupled | CCT8,MYH3,HSPA1B,VPS4B,NSF,MYO1E,HSPA8,HSP104,HSPA1A,ABCB1A |
| protein binding | USP4,PFN1,UBE2Q1,ATP1B2,WT1,PELI2,MEA1,PSME3,AFG3L2,DZIP3 |
Interacting Protein
PEX1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PEX1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PEX1.
PEX6;PEX14;EXOSC2;SMC1A;PEX26
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References
- Miyata, N; Okumoto, K; et al. AWP1/ZFAND6 Functions in Pex5 Export by Interacting with Cys-Monoubiquitinated Pex5 and Pex6 AAA ATPase. TRAFFIC 13:168-183(2012).
- Lamhonwah, AM; Ackerley, CA; et al. OCTN3 is a mammalian peroxisomal membrane carnitine transporter. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 338:1966-1972(2005).
