PEG3
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Official Full Name
paternally expressed 3 -
Overview
Alternative-splicing factor 1 (ASF-1), also known as SRp30a or SF2, is a member of the highly conserved family of SR proteins, a group of serine/arginine-rich domain-containing proteins that play a critical role in regulated and constitutive splicing of precursor mRNA. The SR family of proteins is characterized as having one to two RNA recognition motifs located in the n-terminal sequence, and an RS domain within the C-terminus that is rich in serine/arginine dipeptide repeats. ASF-1 has an inhibitory role in exon skipping, in order to maintain splicing accuracy and to monitor alternative splicing. Studies have shown that ASF-1 plays a role in the regulation of caspase-9 alternative splicing as well as being a critical component for ceramide to function as a mediator of alternative splicing for the same caspase. -
Synonyms
PEG3;paternally expressed 3;paternally-expressed gene 3 protein;KIAA0287;ZNF904;ZSCAN24;Kruppel-type zinc finger protein;zinc finger and SCAN domain-containing protein 24;PW1;DKFZp781A095
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PEG3-12625M | Recombinant Mouse PEG3 Protein | Mammalian Cells | Mouse | His |
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| PEG3-3305HCL | Recombinant Human PEG3 293 Cell Lysate | HEK293 | Human | Non |
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| PEG3-6630M | Recombinant Mouse PEG3 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| PEG3-6630M-B | Recombinant Mouse PEG3 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
PEG3 involved in several pathways and played different roles in them. We selected most pathways PEG3 participated on our site, such as TNF-alpha/NF-kB Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PEG3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| TNF-alpha/NF-kB Signaling Pathway | KPNA6,DPF2,TXLNA,KIAA1967,FAF1,NKIRAS1,ZFAND5,SMARCB1,G3BP2,PDCD2 |
Protein Function
PEG3 has several biochemical functions, for example, RNA polymerase II transcription factor activity, sequence-specific DNA binding,metal ion binding,nucleic acid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PEG3 itself. We selected most functions PEG3 had, and list some proteins which have the same functions with PEG3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| nucleic acid binding | ZFP35,BAT1,WBP4,TRERF1,GLIS2B,HNRNPL2,ZFAT,SALL3,ZNF710A,SCRT2 |
| metal ion binding | ZNF165,ZFPL1,ABAT,TMPPE,BTK,CYP2P9,ADO,ZBTB48,HENMT1,LMAN1 |
| RNA polymerase II transcription factor activity, sequence-specific DNA binding | FOXP1,POU5F1,ZNF496,PHB,TFDP1,JUNBA,FOXO3B,FOXS1,ELF3,SIM1A |
Interacting Protein
PEG3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PEG3 here. Most of them are supplied by our site. Hope this information will be useful for your research of PEG3.
LIMS1;USP7;ssrna_ug;ALB
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