PEF1
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Official Full Name
penta-EF-hand domain containing 1 -
Overview
This gene encodes a calcium-binding protein belonging to the penta-EF-hand protein family. The encoded protein has been shown to form a heterodimer with the programmed cell death 6 gene product and may modulate its function in Ca(2+) signaling. Alternative splicing results in multiple transcript variants and a pseudogene has been identified on chromosome 1. -
Synonyms
PEF1;penta-EF-hand domain containing 1;peflin;PEF1A;ABP32;PEF;PEF protein with a long N terminal hydrophobic domain;Penta EF hand domain containing protein 1;penta-EF hand domain containing 1;PEF protein with a long N-terminal hydrophobic domain
Recombinant Proteins
- Human
- Zebrafish
- Rat
- Mouse
- E.coli
- Mammalian Cell
- HEK293
- Mammalian cells
- HEK293T
- GST
- His
- Non
- T7
- His&Fc&Avi
- Flag
- Myc&DDK
Involved Pathway
PEF1 involved in several pathways and played different roles in them. We selected most pathways PEF1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PEF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
PEF1 has several biochemical functions, for example, calcium ion binding,calcium-dependent cysteine-type endopeptidase activity,poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PEF1 itself. We selected most functions PEF1 had, and list some proteins which have the same functions with PEF1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calcium-dependent cysteine-type endopeptidase activity | CAPN2A,CAPNS1B,CAPN1B,GCA,CAPN10,CAPN12,CAPN2B,CAPN1,CAPN2,CAPNS1A |
| protein dimerization activity | HES2,NUP210,HELT,POLR2J2,ATOH1A,POLR1C,OLIG1,MGAA,AHR,MSC |
| protein binding | APOO,BLM,PIKFYVE,MYH9,CD79B,PIK3R2,RALY,BSG,SPI1B,SEC23B |
| poly(A) RNA binding | TSR1,MRPL9,MRPL42,SERPINH1,RRP9,NGRN,CIRBP,GAR1,DIMT1,TCP1 |
| calcium ion binding | ANXA11,PCDHB15,SRI,THBD,NOTCH2,EML1,FAM20C,MMP25,RYR3,EEF2K |
| protein heterodimerization activity | TERF1,DMRT1,UGT1A3,UBXN6,UGT1A4,H2AFV,BTBD11,HIST3H3,HIST1H2AA,GM5506 |
Interacting Protein
PEF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PEF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PEF1.
PDCD6;KLHL12;CALCOCO2;DAZAP2;CEP55
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References
- Partha, SK; Ravulapalli, R; et al. Crystal structure of calpain-3 penta-EF-hand (PEF) domain - a homodimerized PEF family member with calcium bound at the fifth EF-hand. FEBS JOURNAL 281:3138-3149(2014).
- Osako, Y; Maemoto, Y; et al. Autolytic activity of human calpain 7 is enhanced by ESCRT-III-related protein IST1 through MIT-MIM interaction. FEBS JOURNAL 277:4412-4426(2010).
