PDP1

  • Official Full Name

    pyruvate dehyrogenase phosphatase catalytic subunit 1

  • Overview

    Pyruvate dehydrogenase (E1) is one of the three components (E1, E2, and E3) of the large pyruvate dehydrogenase;complex. Pyruvate dehydrogenase kinases catalyze phosphorylation of serine residues of E1 to inactivate the E1;component and inhibit the complex. Pyruvate dehydrogenase phosphatases catalyze the dephosphorylation and activation;of the E1 component to reverse the effects of pyruvate dehydrogenase kinases. Pyruvate dehydrogenase phosphatase is a;heterodimer consisting of catalytic and regulatory subunits. Two catalytic subunits have been reported; one is;predominantly expressed in skeletal muscle and another one is is much more abundant in the liver. The catalytic;subunit, encoded by this gene, is the former, and belongs to the protein phosphatase 2C (PP2C) superfamily. Along with;the pyruvate dehydrogenase complex and pyruvate dehydrogenase kinases, this enzyme is located in the mitochondrial;matrix. Mutation in this gene causes pyruvate dehydrogenase phosphatase deficiency. Multiple alternatively spliced;transcript variants encoding different isoforms have been identified.

  • Synonyms

    PDP1;pyruvate dehyrogenase phosphatase catalytic subunit 1;PPM2C, protein phosphatase 2C, magnesium dependent, catalytic subunit;[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial;PDH;PDP;PDP 1;PDPC 1;pyruvate dehydrogena

Recombinant Proteins

  • Chicken
  • Zebrafish
  • Human
  • Mouse
  • Mammalian Cell
  • HEK293
  • E.coli
  • HEK293T
  • Mamanlian cells
  • E. coli
  • His
  • Myc&DDK
  • His&T7
  • Non
  • Flag
Cat.# Product name Source (Host) Species Tag Protein Length Price
PDP1-4482C Recombinant Chicken PDP1 Mammalian Cell Chicken His
PDP1-6228Z Recombinant Zebrafish PDP1 Mammalian Cell Zebrafish His
PDP1-695H Recombinant Human PDP1, MYC/DDK-tagged HEK293 Human Myc&DDK
PDP1-696H Recombinant Human PDP1, MYC/DDK-tagged HEK293 Human Myc&DDK
PDP1-698H Recombinant Human PDP1, His-tagged E.coli Human His
PDP1-7881H Recombinant Human PDP1 protein, His & T7-tagged E.coli Human His&T7 Asn315~Glu537
PDP1-3324HCL Recombinant Human PDP1 293 Cell Lysate HEK293 Human Non
Pdp1-4775M Recombinant Mouse Pdp1 Protein, Myc/DDK-tagged HEK293T Mouse Myc&DDK
PDP1-4965H Recombinant Human PDP1 Protein (Asn315-Glu537), N-His tagged E.coli Human His Asn315-Glu537
PDP1-5468HFL Recombinant Full Length Human PDP1, Flag-tagged Mamanlian cells Human Flag Full L.
PDP1-5982H Recombinant Human PDP1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Human Myc&DDK
PDP1-79H Recombinant Human PDP1 Protein, His-tagged E. coli Human His Ala72-Glu537

    Involved Pathway

    PDP1 involved in several pathways and played different roles in them. We selected most pathways PDP1 participated on our site, such as Metabolism,Pyruvate metabolism,Pyruvate metabolism and Citric Acid (TCA) cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Metabolism COX6C,DCT,TYMP,ARSJ,SLC25A32,SCP2B,FA2H,GPC5A,UGT1B3,HIBADHA
    The citric acid (TCA) cycle and respiratory electron transport D2HGDH,PDK2,COX18,COX14,SCO1,UCP2,C2orf56,ADHFE1,ETFDH,PDPR
    Regulation of pyruvate dehydrogenase (PDH) complex PDPR,PDK3,PDK3B,PDK2B,PDK4,PDP2,PDK2
    Pyruvate metabolism and Citric Acid (TCA) cycle SLC16A8,PDP2,PDK2B,PDK4,MPC1,BRP44,ADHFE1,D2HGDH,PDK2,PDPR
    Pyruvate metabolism FH1,ME2,ALDH9A1B,LDHA,MDH1AA,HAGHL,PDK4,GRHPRB,LDHAL6B,PDHA2

    Protein Function

    PDP1 has several biochemical functions, for example, [pyruvate dehydrogenase (lipoamide)] phosphatase activity,metal ion binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PDP1 itself. We selected most functions PDP1 had, and list some proteins which have the same functions with PDP1. You can find most of the proteins on our site.

    Function Related Protein
    protein binding SH3PXD2A,LONP1,KLK4,UBE2A,SRSF3,NUDT4,PYGB,HTR3E,BBS9,IL1RL1
    [pyruvate dehydrogenase (lipoamide)] phosphatase activity PDP2
    protein serine/threonine phosphatase activity PPP3CA,PPM1LA,PPM1K,PPM1DA,PPM1A,PPEF2,PPM1H,DUSP23B,MTMR3,PPP2R2A
    metal ion binding METAP2,ANTXR2B,VEZF1B,MORC2A,ZNF428,ADIPOR1,MUL1B,PDE1A,KLF11,COL9A1

    Interacting Protein

    PDP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PDP1.

    CBFA2T2;PDHA1;yiuR;SIRT4

    Resources

    Research Area

    Phosphatases and Regulators
    Calcium-binding Proteins and Related Molecules

    References

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