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Official Full Name
peptide deformylase (mitochondrial) -
Overview
Protein synthesis proceeds after formylation of methionine by methionyl-tRNA formyl transferase (FMT) and transfer of the charged initiator f-met tRNA to the ribosome. In eubacteria and eukaryotic organelles the product of this gene, peptide deformylase (PDF), removes the formyl group from the initiating methionine of nascent peptides. In eubacteria, deformylation of nascent peptides is required for subsequent cleavage of initiating methionines by methionine aminopeptidase. The discovery that a natural inhibitor of PDF, actinonin, acts as an antimicrobial agent in some bacteria has spurred intensive research into the design of bacterial-specific PDF inhibitors. In human cells, only mitochondrial proteins have N-formylation of initiating methionines. Protein inhibitors of PDF or siRNAs of PDF block the growth of cancer cell lines but have no effect on normal cell growth. In humans, PDF function may therefore be restricted to rapidly growing cells. -
Synonyms
PDF;peptide deformylase (mitochondrial);peptide deformylase, mitochondrial;mitochondrial;DEFM_HUMAN;PDF1A;Peptide deformylase;Polypeptide deformylase;peptide deformylase-like protein
Recombinant Proteins
- Human
- Rhesus macaque
- Zebrafish
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- His
- GST
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PDF-12H | Recombinant Human PDF protein, His-tagged | E.coli | Human | His | 40-243 a.a. |
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| PDF-3354R | Recombinant Rhesus monkey PDF Protein, His-tagged | Mammalian Cell | Rhesus macaque | His |
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| PDF-3411Z | Recombinant Zebrafish PDF | Mammalian Cell | Zebrafish | His |
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| PDF-7830H | Recombinant Human PDF, GST-tagged | Wheat Germ | Human | GST |
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| PDF-3338HCL | Recombinant Human PDF 293 Cell Lysate | HEK293 | Human | Non |
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| PDF-3172R | Recombinant Rhesus Macaque PDF Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| PDF-3172R-B | Recombinant Rhesus Macaque PDF Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| PDF-89H | Recombinant Human PDF protein, His-tagged | E.coli | Human | His |
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Involved Pathway
PDF involved in several pathways and played different roles in them. We selected most pathways PDF participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PDF were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
PDF has several biochemical functions, for example, iron ion binding,peptide deformylase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PDF itself. We selected most functions PDF had, and list some proteins which have the same functions with PDF. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| iron ion binding | HBAA,HIF1AN,TMLHE,HBG1,CYP2AA3,OGFOD2,SC5DL,CYP2AA2,P4HTM,HBA-X |
Interacting Protein
PDF has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDF here. Most of them are supplied by our site. Hope this information will be useful for your research of PDF.
Max;Trip11;ssdna_dtdg;SLC33A1;Nek2;Shoc2;Cdc6;SRPR;BAG6;CENPA;RNASEH2B;Rab3gap1;Tnpo1;Cdc23;Oxnad1;SGTB;TSNAX;PARD6B;Smc1a;Smc3
Resources
Related Services
Related Products
References
- Vazquez, S; Lozano, C; et al. Dengue Specific Immunoglobulins M, A, and E in Primary and Secondary Dengue 4 Infected Salvadorian Children. JOURNAL OF MEDICAL VIROLOGY 86:1576-1583(2014).
- Hobbs, CK; Leung, M; et al. CIG-P: Circular Interaction Graph for Proteomics. BMC BIOINFORMATICS 15:-(2014).
