PDE11A

  • Official Full Name

    phosphodiesterase 11A

  • Overview

    The 3,5-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3,5-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a member of the PDE protein superfamily. Mutations in this gene are a cause of Cushing disease and adrenocortical hyperplasia. Multiple transcript variants encoding different isoforms have been found for this gene.

  • Synonyms

    PDE11A;phosphodiesterase 11A;dual 3,5-cyclic-AMP and -GMP phosphodiesterase 11A;cAMP and cGMP cyclic nucleotide phosphodiesterase 11A;PPNAD2;FLJ23693;MGC133355;MGC133356

Recombinant Proteins

  • Mouse
  • Rat
  • Human
  • Mammalian Cells
  • Sf9 Cells
  • HEK293
  • His
  • GST
  • Non
  • His&Fc&Avi
  • Flag
  • Myc&DDK

    Involved Pathway

    PDE11A involved in several pathways and played different roles in them. We selected most pathways PDE11A participated on our site, such as Purine metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDE11A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Purine metabolism CECR1,POLR3K,NUDT16,POLE4,XDH,NUDT5,POLD4,POLR3B,NT5C2,PKMA

    Protein Function

    PDE11A has several biochemical functions, for example, 3,5-cyclic-GMP phosphodiesterase activity,3,5-cyclic-nucleotide phosphodiesterase activity,cAMP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PDE11A itself. We selected most functions PDE11A had, and list some proteins which have the same functions with PDE11A. You can find most of the proteins on our site.

    Function Related Protein
    cGMP binding PDE6H,CNGA3,PDE6G,PRKG1A,PRKG2,CNGA4,CNGA2,PDE10A,PDE5A,CNGA1
    3,5-cyclic-nucleotide phosphodiesterase activity PDE8B,PDE4D,PDE10A,PDE8A,PDE9A,PDE5AB,PDE3B,PDE5A,PDE6D
    cyclic-nucleotide phosphodiesterase activity TDP2B,PDE2A,USB1
    cGMP-stimulated cyclic-nucleotide phosphodiesterase activity USB1,PDE2A,PDE10A,TDP2B
    metal ion binding MT4,TGM4,ZNF26,ZFP771,GLI4,HIC2,CNDP1,DICER1,EGR2A,POLL
    3,5-cyclic-GMP phosphodiesterase activity PDE6A,PDE6C,PDE6G,PDE5A,PDE6B,PDE10A,PDE9A,PDE6H
    cAMP binding HCN4,PDE3A,PDE10A,PDE4A,PRKAR2B,PDE4D,CNMPD1,CNGA2,PDE2A,PRKAR1A

    Interacting Protein

    PDE11A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDE11A here. Most of them are supplied by our site. Hope this information will be useful for your research of PDE11A.

    Resources

    References

    • Uckert, S; Waldkirch, ES; et al. Expression and Distribution of Phosphodiesterase Isoenzymes in the Human Seminal Vesicles. JOURNAL OF SEXUAL MEDICINE 8:3058-3065(2011).
    • Tadjine, M; Lampron, A; et al. Detection of somatic beta-catenin mutations in primary pigmented nodular adrenocortical disease (PPNAD). CLINICAL ENDOCRINOLOGY 69:367-373(2008).

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