PCSK1
-
Official Full Name
proprotein convertase subtilisin/kexin type 1 -
Overview
This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to subcellular compartments where a second autocatalytic even takes place and the catalytic activity is acquired. The protease is packaged into and activated in dense core secretory granules and expressed in the neuroendocrine system and brain. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It functions in the proteolytic activation of polypeptide hormones and neuropeptides precursors. Mutations in this gene have been associated with susceptibility to obesity and proprotein convertase 1/3 deficiency. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene [provided by RefSeq, Jan 2014] -
Synonyms
PCSK1;proprotein convertase subtilisin/kexin type 1;PC1;PC3;NEC1;SPC3;BMIQ12;neuroendocrine convertase 1;prohormone convertase 1;prohormone convertase 3
Recombinant Proteins
- Human
- Mouse
- Rat
- Zebrafish
- HEK293
- E.coli
- Mammalian Cells
- Human Cells
- Yeast
- His
- GST
- His&T7
- Non
- His&Fc&Avi
Involved Pathway
PCSK1 involved in several pathways and played different roles in them. We selected most pathways PCSK1 participated on our site, such as Incretin synthesis, secretion, and inactivation,Insulin processing,Metabolism of proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with PCSK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) | GPR119,DPP4 |
| Insulin processing | KIF5B,EXOC1,PCSK2,EXOC6,KIF5A,SLC30A6,EXOC5,EXOC8,SLC30A8,CPE |
| Peptide hormone biosynthesis | INHBAA,CGB7,INHA,CGB5 |
| Incretin synthesis, secretion, and inactivation | SPCS3,GPR120,DPP4,GPR119,O3far1,CDX2,SLC38A8,GRP |
| Synthesis, secretion, and deacylation of Ghrelin | SLC38A8,MBOAT4,SPCS3 |
| Metabolism of proteins | CTDSP2,CALCA,MPDU1,NAT8,DCP2,ALG10B,TRAPPC2L,LMAN2L,ADAMTS8,GFER |
| Peptide hormone metabolism | INHBAA,CGB5,CPB2,BCHE,CMA1,RAB27A,CGB7,EXOC8,O3far1,CPA3 |
Protein Function
PCSK1 has several biochemical functions, for example, serine-type endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PCSK1 itself. We selected most functions PCSK1 had, and list some proteins which have the same functions with PCSK1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| serine-type endopeptidase activity | FURINB,TMPRSS13A,F2,TMPRSS4,PRSS42,KLK6,CFI,HTRA1A,PCSK4,F12 |
Interacting Protein
PCSK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PCSK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PCSK1.
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References
- Berger, JM; Vaillant, N; et al. PCSK9-deficiency does not alter blood pressure and sodium balance in mouse models of hypertension. ATHEROSCLEROSIS 239:252-259(2015).
- de Keyser, CE; Becker, ML; et al. The rs13064411 polymorphism in the WDR52 gene, associated with PCSK9 levels, modifies statin-induced changes in serum total and LDL cholesterol levels. PHARMACOGENETICS AND GENOMICS 25:134-142(2015).
