PCK2

  • Official Full Name

    phosphoenolpyruvate carboxykinase 2 (mitochondrial)

  • Overview

    This gene encodes a mitochondrial enzyme that catalyzes the conversion of oxaloacetate to phosphoenolpyruvate in the presence of guanosine triphosphate (GTP). A cytosolic form of this protein is encoded by a different gene and is the key enzyme of gluconeogenesis in the liver. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2014]

  • Synonyms

    PCK2;phosphoenolpyruvate carboxykinase 2 (mitochondrial);PEPCK;PEPCK2;PEPCK-M;phosphoenolpyruvate carboxykinase [GTP], mitochondrial;PEP carboxykinase;phosphopyruvate carboxylase;phosphoenolpyruvate carboxylase

Recombinant Proteins

  • Human
  • Zebrafish
  • Rhesus macaque
  • Chicken
  • E.coli
  • Mammalian Cell
  • HEK293
  • Insect Cell
  • His
  • GST
  • Non
  • His&Fc&Avi
  • His&GST
Cat.# Product name Source (Host) Species Tag Protein Length Price
PCK2-3016H Recombinant Human PCK2 protein, His-tagged E.coli Human His 292-640 aa
PCK2-3280H Recombinant Human PCK2 protein, GST-tagged E.coli Human GST 292-640 aa
PCK2-12403Z Recombinant Zebrafish PCK2 Mammalian Cell Zebrafish His
PCK2-3327R Recombinant Rhesus monkey PCK2 Protein, His-tagged Mammalian Cell Rhesus macaque His
PCK2-7019C Recombinant Chicken PCK2 Mammalian Cell Chicken His
PCK2-8087H Recombinant Human PCK2 protein, His-tagged E.coli Human His Leu33~Val198
PCK2-3378HCL Recombinant Human PCK2 293 Cell Lysate HEK293 Human Non
PCK2-3145R Recombinant Rhesus Macaque PCK2 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque His&Fc&Avi
PCK2-3145R-B Recombinant Rhesus Macaque PCK2 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
PCK2-4810H Recombinant Human PCK2 Protein (Ala292-Met640), N-His tagged E.coli Human His Ala292-Met640
PCK2-513H Recombinant Human PCK2 Protein, His/GST-tagged Insect Cell Human His&GST Leu33-Met640

    Involved Pathway

    PCK2 involved in several pathways and played different roles in them. We selected most pathways PCK2 participated on our site, such as Glycolysis / Gluconeogenesis,Citrate cycle (TCA cycle),Pyruvate metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with PCK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Proximal tubule bicarbonate reclamation FXYD2,ATP1B2,SLC25A10,MDH1,GLS,SLC4A4,Car4,Car2,PCK1,ATP1B4
    Citrate cycle (TCA cycle) ACLYA,ACO2,MDH2,PDHB,PDHA1,SDHDB,PCXB,ACLY,ACO1,PDHA1A
    PIK-Akt signaling pathway IL2RB,ITGB3,IFNA8,ANGPT1,YWHAE,INS2,RPS6KB2,Ifna11,FGFR1,TRP53
    PPAR signaling pathway SLC27A5,PPARAB,FADS2,RXRB,FABP3,FABP7,PDPK1B,GK2,SLC27A2,PPARA
    AMPK signaling pathway PIK3R2,TSC1,CD36,Scd1,PPP2R5A,PPP2R3C,INS,PRKAG2,PPP2R2B,CCNA1
    Insulin signaling pathway TRIP10,PHKA2,LIPE,SOS1,PHKG1B,PTPN1,GYS1,SHC2,PPP1R3CA,PHKG1
    Pyruvate metabolism FH1,MDH2,PKLR,PDHA1B,ALDH3A2A,PKM,LDHB,HAGHL,ACSS2L,GRHPRA
    Glycolysis / Gluconeogenesis FBP1B,ALDH2.1,PKLR,G6PC,MINPP1B,HK3,ALDH3A2A,ADH4,ACSS1,PDHA1A
    Adipocytokine signaling pathway G6PC2,PRKAG2,PRKAG2A,PPARGC1A,PTPN11A,CAMKK2,IRS1,G6PC,PRKAA2,SLC2A4

    Protein Function

    PCK2 has several biochemical functions, for example, GTP binding,metal ion binding,phosphoenolpyruvate carboxykinase (GTP) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PCK2 itself. We selected most functions PCK2 had, and list some proteins which have the same functions with PCK2. You can find most of the proteins on our site.

    Function Related Protein
    phosphoenolpyruvate carboxykinase (GTP) activity PCK1
    metal ion binding BTR02,DOHH,SP7,PHOSPHO2,ESCO1,ZKSCAN17,ZBTB8A,NAIP6,UQCRC2A,FBXO30A
    GTP binding RASEF,SRP54B,TUBB4B,SEPT11,RAB6A,TUBA1L2,EIF5B,SEPT5,EIF2S3Y,RASL10B
    protein binding PTPRC,ZFP346,CAB39,FAM119A,BCL9,TTC23L,FAM9C,SMAD1,PIH1D3,USP19
    phosphoenolpyruvate carboxykinase activity PDXDC1

    Interacting Protein

    PCK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PCK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PCK2.

    SMAD3;EP300;mhpC2;q81la6_bacan;q81pd4_bacan;icc;def;ere_dna;PROSC;HSPD1;PRCC;TSG101;MUC13;CWC15;SIRT4

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