PCGF6

  • Official Full Name

    polycomb group ring finger 6

  • Overview

    The protein encoded by this gene contains a RING finger motif, which is most closely related to those of polycomb group (PcG) proteins RNF110/MEL-18 and BMI1. PcG proteins are known to form protein complexes and function as transcription repressors. This protein has been shown to interact with some PcG proteins and act as a transcription repressor. The activity of this protein is found to be regulated by cell cycle dependent phosphorylation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

  • Synonyms

    PCGF6;polycomb group ring finger 6;MBLR;RNF134;polycomb group RING finger protein 6;ring finger protein 134;Mel18 and Bmi1-like RING finger protein

Recombinant Proteins

  • Mouse
  • Rhesus macaque
  • Rat
  • Zebrafish
  • Human
  • Mammalian Cell
  • HEK293
  • His
  • Non
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
PCGF6-12493M Recombinant Mouse PCGF6 Protein Mammalian Cell Mouse His
PCGF6-3326R Recombinant Rhesus monkey PCGF6 Protein, His-tagged Mammalian Cell Rhesus macaque His
PCGF6-4298R Recombinant Rat PCGF6 Protein Mammalian Cell Rat His
PCGF6-5521Z Recombinant Zebrafish PCGF6 Mammalian Cell Zebrafish His
PCGF6-1310HCL Recombinant Human PCGF6 cell lysate Human Non
PCGF6-3144R Recombinant Rhesus Macaque PCGF6 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque His&Fc&Avi
PCGF6-3144R-B Recombinant Rhesus Macaque PCGF6 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
PCGF6-3960R Recombinant Rat PCGF6 Protein, His (Fc)-Avi-tagged HEK293 Rat His&Fc&Avi
PCGF6-3960R-B Recombinant Rat PCGF6 Protein Pre-coupled Magnetic Beads HEK293 Rat
PCGF6-6551M Recombinant Mouse PCGF6 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
PCGF6-6551M-B Recombinant Mouse PCGF6 Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    PCGF6 involved in several pathways and played different roles in them. We selected most pathways PCGF6 participated on our site, such as Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with PCGF6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Signaling pathways regulating pluripotency of stem cells PIK3CD,ESRRB,SMAD2,MYF5,INHBA,ONECUT1,PIK3R1,NRAS,PIK3CG,ACVR1C

    Protein Function

    PCGF6 has several biochemical functions, for example, DNA binding,RNA polymerase II regulatory region sequence-specific DNA binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PCGF6 itself. We selected most functions PCGF6 had, and list some proteins which have the same functions with PCGF6. You can find most of the proteins on our site.

    Function Related Protein
    transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding MNT,HMX1,AEBP1,FOXD3,MITF,FOXO3,NFKB1,BCL6A,NR2F6,GLIS1
    DNA binding INSM2,MIER3,ZNF276,NFIL3,MYCA,HISTH1L,SSRP1,DDX41,NABP2,ATF4
    RNA polymerase II regulatory region sequence-specific DNA binding TFAP2C,TAL1,GATA3,RXRG,GATA2B,NR1D1,ZIK1,SNAI1,PLAGL1,STAT4
    protein binding MFN1,FHL1,AGXT2L2,TNPO2,CTSB,C8orf33,Car8,STAG1,FAT4,TAF8
    zinc ion binding RNF20,DNPEP,TEX13A,FTR50,CAR7,NPSN,VAT1L,RNF217,USP13,ZNFL1
    transcription factor activity, sequence-specific DNA binding PPARDB,PHF1,ZNF789,RXRAA,HIST1H2AH,TADA2A,ZNF79,ZFP161,IRF9,POU2F1B

    Interacting Protein

    PCGF6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PCGF6 here. Most of them are supplied by our site. Hope this information will be useful for your research of PCGF6.

    RNF2;Cbx7;CBX7;CBX8;CBX4;CBX6;HSP90AB1;PRKAB1;PEX10;TULP3;RING1;UBE2U;PNMA1;RAD18;Ring1

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