PCGF2
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Official Full Name
polycomb group ring finger 2 -
Overview
The protein encoded by this gene contains a RING finger motif and is similar to the polycomb group (PcG) gene products. PcG gene products form complexes via protein-protein interaction and maintain the transcription repression of genes involved in embryogenesis, cell cycles, and tumorigenesis. This protein was shown to act as a negative regulator of transcription and has tumor suppressor activity. The expression of this gene was detected in various tumor cells, but is limited in neural organs in normal tissues. Knockout studies in mice suggested that this protein may negatively regulate the expression of different cytokines, chemokines, and chemokine receptors, and thus plays an important role in lymphocyte differentiation and migration, as well as in immune responses. [provided by RefSeq, Jul 2008] -
Synonyms
PCGF2;polycomb group ring finger 2;MEL-18;RNF110;ZNF144;polycomb group RING finger protein 2;ring finger protein 110;zinc finger protein 144;DNA-binding protein Mel-18
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PCGF2-3324R | Recombinant Rhesus monkey PCGF2 Protein, His-tagged | Mammalian Cell | Rhesus macaque | His |
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| PCGF2-5424C | Recombinant Chicken PCGF2 | Mammalian Cell | Chicken | His |
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| PCGF2-3382HCL | Recombinant Human PCGF2 293 Cell Lysate | HEK293 | Human | Non |
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| PCGF2-3142R | Recombinant Rhesus Macaque PCGF2 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| PCGF2-3142R-B | Recombinant Rhesus Macaque PCGF2 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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Involved Pathway
PCGF2 involved in several pathways and played different roles in them. We selected most pathways PCGF2 participated on our site, such as Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with PCGF2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Signaling pathways regulating pluripotency of stem cells | HNF1A,AKT2,FZD9,IGF1R,PCGF3,NODAL,BMPR1B,HAND1,PAX6,ACVR1C |
Protein Function
PCGF2 has several biochemical functions, for example, DNA binding,chromatin binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PCGF2 itself. We selected most functions PCGF2 had, and list some proteins which have the same functions with PCGF2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| chromatin binding | ARNTL1B,NEUROG1,BAP1,ATAD2B,HHEX,TOP1,CDCA5,NKX2-5,SKIL,RAD51 |
| zinc ion binding | RORB,FAM90A1,ZCRB1,ALPP,TRIM35-39,Alb,BRF2,ADAMTSL1,TAB3,ZDHHC3 |
| DNA binding | LIG1,NR2F6B,ZHX3,Trl,ZFP639,DNAJB6,MCM3,ZBTB24,HER4.2,ZNF471 |
| transcription factor activity, sequence-specific DNA binding | ZNF323,CTBP1,FOXF2A,HOXB3A,HOXB5A,CSRNP1,ZSCAN20,SOX2,MAFBB,ATF5 |
| protein binding | THSD4,SH3GLB2,KBTBD7,PROX1,THY1,SEMA7A,LSM4,KLF12,ARNTL2,STOM |
Interacting Protein
PCGF2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PCGF2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PCGF2.
RNF2;CBX8;PHC2
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References
- Sun, J; Wang, J; et al. Knockdown of Polycomb-Group RING Finger 6 Modulates Mouse Male Germ Cell Differentiation in Vitro. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY 35:339-352(2015).
- Wakeel, A; Kuriakose, JA; et al. An Ehrlichia chaffeensis Tandem Repeat Protein Interacts with Multiple Host Targets Involved in Cell Signaling, Transcriptional Regulation, and Vesicle Trafficking. INFECTION AND IMMUNITY 77:1734-1745(2009).
