PCDHB6
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Official Full Name
protocadherin beta 6 -
Overview
This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3 exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections. -
Synonyms
PCDHB6;protocadherin beta 6;protocadherin beta-6;PCDH BETA6;PCDHB 6;PCDH-beta-6;OTTHUMP00000160023;PCDH-BETA6
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PCDHB6-3390HCL | Recombinant Human PCDHB6 293 Cell Lysate | HEK293 | Human | Non |
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| PCDHB6-1917H | Recombinant Human PCDHB6 Protein, His-tagged | E.coli | Human | His | Glu39-Pro251 |
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| Pcdhb6-1918M | Recombinant Mouse Pcdhb6 Protein, His-tagged | E.coli | Mouse | His | Leu75-Gly275 |
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Involved Pathway
PCDHB6 involved in several pathways and played different roles in them. We selected most pathways PCDHB6 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PCDHB6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
PCDHB6 has several biochemical functions, for example, calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PCDHB6 itself. We selected most functions PCDHB6 had, and list some proteins which have the same functions with PCDHB6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calcium ion binding | CHP2,ANXA9,CCDC167,PPP3CA,DMP1,CDH1,NUCB2A,GUCA1D,CHP,GUCA1G |
Interacting Protein
PCDHB6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PCDHB6 here. Most of them are supplied by our site. Hope this information will be useful for your research of PCDHB6.
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References
- Lv, J; Zhu, P; et al. PCDH20 functions as a tumour-suppressor gene through antagonizing the Wnt/beta-catenin signalling pathway in hepatocellular carcinoma. JOURNAL OF VIRAL HEPATITIS 22:201-211(2015).
- van Helden, YGJ; Godschalk, RWL; et al. Organ specificity of beta-carotene induced lung gene-expression changes in Bcmo1(-/-) mice. MOLECULAR NUTRITION & FOOD RESEARCH 57:307-319(2013).
