PCDHB10
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Official Full Name
protocadherin beta 10 -
Overview
This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3 exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections. -
Synonyms
PCDHB10;protocadherin beta 10;protocadherin beta-10;OTTHUMP00000160026;PCDBA_HUMAN;PCDH BETA10;PCDH-beta-10;PCHB10;PCDH-BETA10
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PCDHB10-1560H | Recombinant Human PCDHB10, His-tagged | E.coli | Human | His | 400-696aa | |
| PCDHB10-1914H | Recombinant Human PCDHB10 Protein, His-tagged | E.coli | Human | His | Thr64-Asp270 |
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Involved Pathway
PCDHB10 involved in several pathways and played different roles in them. We selected most pathways PCDHB10 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PCDHB10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
PCDHB10 has several biochemical functions, for example, calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PCDHB10 itself. We selected most functions PCDHB10 had, and list some proteins which have the same functions with PCDHB10. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calcium ion binding | DSG3,NCL,SYT9B,ELTD1,ANXA1C,NCAN,THBS3A,SYT11,NCS1B,EFCAB1 |
Interacting Protein
PCDHB10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PCDHB10 here. Most of them are supplied by our site. Hope this information will be useful for your research of PCDHB10.
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References
- Zhao, Y; Yang, YH; et al. A Novel Wnt Regulatory Axis in Endometrioid Endometrial Cancer. CANCER RESEARCH 74:5103-5117(2014).
- Wojtalewicz, N; Sadeqzadeh, E; et al. A Soluble Form of the Giant Cadherin Fat1 Is Released from Pancreatic Cancer Cells by ADAM10 Mediated Ectodomain Shedding. PLOS ONE 9:-(2014).
