PCDHA8
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Official Full Name
protocadherin alpha 8 -
Overview
This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined. -
Synonyms
PCDHA8;protocadherin alpha 8;protocadherin alpha-8;KIAA0345 like 6;PCDH ALPHA8;PCDH-alpha-8;KIAA0345-like 6;PCDH-ALPHA8
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PCDHA8-3787C | Recombinant Chicken PCDHA8 | Mammalian Cell | Chicken | His |
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| PCDHA8-1297HCL | Recombinant Human PCDHA8 cell lysate | Human | Non |
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| Pcdha8-1912R | Recombinant Rat Pcdha8 Protein, His-tagged | E.coli | Rat | His | Gln30-Thr260 |
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Involved Pathway
PCDHA8 involved in several pathways and played different roles in them. We selected most pathways PCDHA8 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PCDHA8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
PCDHA8 has several biochemical functions, for example, calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PCDHA8 itself. We selected most functions PCDHA8 had, and list some proteins which have the same functions with PCDHA8. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calcium ion binding | PCDH1A3,CRACR2B,CAPSLA,GSNA,CACNA1SA,CA,PCDH1G9,SLC25A23,ANXA2A,MBL2 |
Interacting Protein
PCDHA8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PCDHA8 here. Most of them are supplied by our site. Hope this information will be useful for your research of PCDHA8.
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