PCDHA6
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Official Full Name
protocadherin alpha 6 -
Overview
This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined. -
Synonyms
PCDHA6;protocadherin alpha 6;CNRS2;protocadherin alpha-6;CNR2;CRNR2;KIAA0345 like 8;PCDH ALPHA6;Cadherin related neuronal receptor 2;CNR 2;CNRN 2;CNRN2;CNRS 2;CRNR 2;PCDHA 6;PCDH-alpha-6;KIAA0345-like 8;OTTHUMP00000223649;OTTHUMP00000232599;PCDH-ALPHA6
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PCDHA6-169H | Recombinant Human PCDHA6, His-tagged | HEK293 | Human | His | 30-697 a.a. |
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| PCDHA6-3396HCL | Recombinant Human PCDHA6 293 Cell Lysate | HEK293 | Human | Non |
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Involved Pathway
PCDHA6 involved in several pathways and played different roles in them. We selected most pathways PCDHA6 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PCDHA6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
PCDHA6 has several biochemical functions, for example, calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PCDHA6 itself. We selected most functions PCDHA6 had, and list some proteins which have the same functions with PCDHA6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calcium ion binding | HSPA5,ACTN4,CDH2,PCDHGB2,SCUBE3,CAPSL,FBLN1,FSTL1A,EFCAB7,RCN1 |
Interacting Protein
PCDHA6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PCDHA6 here. Most of them are supplied by our site. Hope this information will be useful for your research of PCDHA6.
CRK;BRK1
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References
- Wang, KH; Lin, CJ; et al. Global methylation silencing of clustered proto-cadherin genes in cervical cancer: serving as diagnostic markers comparable to HPV. CANCER MEDICINE 4:43-55(2015).
- Appenzeller, S; Helbig, I; et al. Febrile infection-related epilepsy syndrome (FIRES) is not caused by SCN1A, POLG, PCDH19 mutations or rare copy number variations. DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY 54:1144-1148(2012).
