PCDHA5
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Official Full Name
protocadherin alpha 5 -
Overview
This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined. -
Synonyms
PCDHA5;protocadherin alpha 5;CNRS6;protocadherin alpha-5;CNR6;CNRN6;CRNR6;KIAA0345 like 9;ortholog of mouse CNR6;PCDH ALPHA5;Cadherin related neuronal receptor 6;CNR 6;CNRN 6;CNRS 6;CRNR 6;PCDHA 5;PCDH-alpha-5;KIAA0345-like 9;OTTHUMP00000223676;OTTHUMP00000232598;PCDH-ALPHA5
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PCDHA5-1557H | Recombinant Human PCDHA5, GST-tagged | E.coli | Human | GST | 29-400aa | |
| PCDHA5-3784C | Recombinant Chicken PCDHA5 | Mammalian Cell | Chicken | His |
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Involved Pathway
PCDHA5 involved in several pathways and played different roles in them. We selected most pathways PCDHA5 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PCDHA5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
PCDHA5 has several biochemical functions, for example, calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PCDHA5 itself. We selected most functions PCDHA5 had, and list some proteins which have the same functions with PCDHA5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calcium ion binding | MASP2,ITSN1,SLIT1A,PLSCR1,MMP30,CDK5R1,THBS3B,LRP2,SPOCK2,EFCAB3 |
Interacting Protein
PCDHA5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PCDHA5 here. Most of them are supplied by our site. Hope this information will be useful for your research of PCDHA5.
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References
- Kaneko, R; Abe, M; et al. Expansion of stochastic expression repertoire by tandem duplication in mouse Protocadherin-alpha cluster. SCIENTIFIC REPORTS 4:-(2014).
- Asahina, H; Masuba, A; et al. DISTRIBUTION OF PROTOCADHERIN 9 PROTEIN IN THE DEVELOPING MOUSE NERVOUS SYSTEM. NEUROSCIENCE 225:88-104(2012).
