PBX4
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Official Full Name
pre-B-cell leukemia homeobox 4 -
Overview
This gene encodes a member of the pre-B cell leukemia transcription factor family. These proteins are homeobox proteins that play critical roles in embryonic development and cellular differentiation both as Hox cofactors and through Hox-independent pathways. The encoded protein contains a homeobox DNA-binding domain, but specific functions of the protein have not been determined. Alternatively spliced transcript variants have been observed for this gene. -
Synonyms
PBX4;pre-B-cell leukemia homeobox 4;pre B cell leukemia transcription factor 4;pre-B-cell leukemia transcription factor 4;OTTMUSP00000045221;2410015M21Rik;AI429113;AW045266;Edg4;Endothelial differentiation, lysophosphatidic acid G protein coupled receptor 4;Homeobox protein PBX4;PBX4_HUMAN
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PBX4-1543H | Recombinant Human PBX4, GST-tagged | E.coli | Human | GST | C-97aa | |
| PBX4-12409M | Recombinant Mouse PBX4 Protein | Mammalian Cell | Mouse | His |
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| PBX4-144H | Recombinant Human PBX4 Protein, HIS-tagged | E.coli | Human | HIS |
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| PBX4-9015Z | Recombinant Zebrafish PBX4 | Mammalian Cell | Zebrafish | His |
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| PBX4-6528M | Recombinant Mouse PBX4 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| PBX4-6528M-B | Recombinant Mouse PBX4 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
PBX4 involved in several pathways and played different roles in them. We selected most pathways PBX4 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PBX4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
PBX4 has several biochemical functions, for example, protein binding,sequence-specific DNA binding,transcription factor activity, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PBX4 itself. We selected most functions PBX4 had, and list some proteins which have the same functions with PBX4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription factor activity, sequence-specific DNA binding | POU5F1,ZBTB14,ZFHX3,ZNF192,HEYL,NFIL3-5,EGR3,GTF2H2,RXRA,HER5 |
| sequence-specific DNA binding | Ar,ASCL1A,HOXC9A,MNX1,DHARMA,DLX4B,TBX1,TBX3,VRTN,SOX2 |
| protein binding | TGOLN2,NUDT1,EFNA1,MOAP1,PALM,POLH,SUPT4H1,HIST1H2AG,GNPDA1,RFC4 |
Interacting Protein
PBX4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PBX4 here. Most of them are supplied by our site. Hope this information will be useful for your research of PBX4.
IPO13;TFIP11
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References
- Arrington, CB; Dowse, BR; et al. Non-synonymous variants in pre-B cell leukemia homeobox (PBX) genes are associated with congenital heart defects. EUROPEAN JOURNAL OF MEDICAL GENETICS 55:235-237(2012).
- Zhu, XL; Ai, ZH; et al. Weighted Gene Co-expression Network Analysis in Identification of Endometrial Cancer Prognosis Markers. ASIAN PACIFIC JOURNAL OF CANCER PREVENTION 13:4607-4611(2012).
