PBX3
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Official Full Name
pre-B-cell leukemia homeobox 3 -
Overview
Pre-B-cell leukemia transcription factor 3 is a protein that in humans is encoded by the PBX3 gene. -
Synonyms
PBX3;pre-B-cell leukemia homeobox 3;pre B cell leukemia transcription factor 3;pre-B-cell leukemia transcription factor 3;homeobox protein PBX3
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PBX3-1542H | Recombinant Human PBX3, GST-tagged | E.coli | Human | GST | 1-43aa | |
| PBX3-2382C | Recombinant Chicken PBX3 | Mammalian Cell | Chicken | His |
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Involved Pathway
PBX3 involved in several pathways and played different roles in them. We selected most pathways PBX3 participated on our site, such as Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with PBX3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Transcriptional misregulation in cancer | FEV,KDM6A,GRIA3,TSPAN7,HMGA2,ETV1,SPINT1,SFPI1,PTK2,HIST1H3H |
Protein Function
PBX3 has several biochemical functions, for example, RNA polymerase II distal enhancer sequence-specific DNA binding,transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PBX3 itself. We selected most functions PBX3 had, and list some proteins which have the same functions with PBX3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA polymerase II distal enhancer sequence-specific DNA binding | NFE2L2,NFE2L1,JUN,NFKB1,NR1H4,BACH2,H3F3B,NFATC1,SFPI1,NR5A2 |
| transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding | HOXB5,ZEB2,MEOX2,NFATC1,FOXH1,SIX6,BACH1,CUX1,HCFC1,FUBP1 |
Interacting Protein
PBX3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PBX3 here. Most of them are supplied by our site. Hope this information will be useful for your research of PBX3.
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References
- Han, HB; Gu, J; et al. PBX3 promotes migration and invasion of colorectal cancer cells via activation of MAPK/ERK signaling pathway. WORLD JOURNAL OF GASTROENTEROLOGY 20:18260-18270(2014).
- Risolino, M; Mandia, N; et al. Transcription factor PREP1 induces EMT and metastasis by controlling the TGF-beta-SMAD3 pathway in non-small cell lung adenocarcinoma. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 111:E3775-E3784(2014).
