PATZ1

  • Official Full Name

    POZ (BTB) and AT hook containing zinc finger 1

  • Overview

    The protein encoded by this gene contains an A-T hook DNA binding motif which usually binds to other DNA binding structures to play an important role in chromatin modeling and transcription regulation. Its Poz domain is thought to function as a site for protein-protein interaction and is required for transcriptional repression, and the zinc-fingers comprise the DNA binding domain. Since the encoded protein has typical features of a transcription factor, it is postulated to be a repressor of gene expression. In small round cell sarcoma, this gene is fused to EWS by a small inversion of 22q, then the hybrid is thought to be translocated (t(1;22)(p36.1;q12). The rearrangement of chromosome 22 involves intron 8 of EWS and exon 1 of this gene creating a chimeric sequence containing the transactivation domain of EWS fused to zinc finger domain of this protein. This is a distinct example of an intra-chromosomal rearrangement of chromosome 22. Four alternatively spliced transcript variants are described for this gene.

  • Synonyms

    PATZ1;POZ (BTB) and AT hook containing zinc finger 1;zinc finger protein 278 , ZNF278;POZ-, AT hook-, and zinc finger-containing protein 1;dJ400N23;MAZR;PATZ;RIAZ;ZBTB19;ZSG;8430401L15Rik;AI447519;BTB POZ domain zinc finger transcription factor;POZ , AT hook, and zinc finger containing protein 1;Protein kinase A RI subunit alpha associated protein;Transcription factor MAZR;Zfp278;Zinc finger and BTB domain containing protein 19;Zinc finger protein 278;Zinc finger protein 278, isoform CRA_d;Zinc finger sarcoma gene protein;ZNF278;MAZ-related factor;POZ-AT hook-zinc finger protein;BTB-POZ domain zinc finger transcription factor;BTB/POZ domain zinc finger transcription factor;zinc finger and BTB domain-containing protein 19;protein kinase A RI subunit alpha-associated protein
Cat.# Product name Source (Host) Species Tag Protein Length Price
PATZ1-048H Recombinant Human PATZ1 Protein, HIS-tagged E.coli Human HIS
PATZ1-049H Recombinant Human PATZ1 Protein, HIS-tagged E.coli Human HIS
PATZ1-3421HCL Recombinant Human PATZ1 293 Cell Lysate HEK293 Human Non
PATZ1-3422HCL Recombinant Human PATZ1 293 Cell Lysate HEK293 Human Non

    Involved Pathway

    PATZ1 involved in several pathways and played different roles in them. We selected most pathways PATZ1 participated on our site, such as Androgen receptor signaling pathway,Coregulation of Androgen receptor activity, which may be useful for your reference. Also, other proteins which involved in the same pathway with PATZ1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Androgen receptor signaling pathway DAXX,KAT5,ETV5A,RAD54L2,CARM1,EGFR,PIAS3,RAD9A,TGFB1I1,SVILA
    Coregulation of Androgen receptor activity CMTM2,NRIP1,TMF1,PAWR,MAK,PIAS3,TGFB1I1,KDM1A,ZMIZ1,TCF4

    Protein Function

    PATZ1 has several biochemical functions, for example, DNA binding,RNA polymerase II core promoter proximal region sequence-specific DNA binding,chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PATZ1 itself. We selected most functions PATZ1 had, and list some proteins which have the same functions with PATZ1. You can find most of the proteins on our site.

    Function Related Protein
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding TFAP2A,BATF,RUNX2,GATA3,KLF13,ARNT2,CTCFL,CREB3,TP73,STAT3
    chromatin binding SOD3,MEIS3,TOP2A,BAHD1,MTA1,RAG2,NCOA1,GLI1,DLX2,MAZ
    DNA binding ZFP513,ZFP775,MYCB,CSDC2A,ZNF26,GCM1,ERG,FUS,HOXB6B,ZNF157
    RNA polymerase II core promoter proximal region sequence-specific DNA binding NRF1,ZKSCAN3,CC2D1B,NFYC,CDX4,NFIA,KLF13,GMEB2,JUNB,TXK
    metal ion binding S100T,TRAF4B,ZNF192,ITGA7,ZKSCAN4,RPL37A,ZFP74,GZF1,ZC3HAV1,MFI2

    Interacting Protein

    PATZ1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PATZ1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PATZ1.

    ssdna_dn

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