PARVB

  • Official Full Name

    parvin, beta

  • Overview

    This gene encodes a member of the parvin family of actin-binding proteins, which play a role in cytoskeleton organization and cell adhesion. These proteins are associated with focal contacts and contain calponin homology domains that bind to actin filaments. This family member binds to alphaPIX and alpha-actinin, and it can inhibit the activity of integrin-linked kinase. This protein also functions in tumor suppression. Alternative splicing of this gene results in multiple transcript variants.

  • Synonyms

    PARVB;parvin, beta;beta-parvin;affixin;CGI 56;Beta parvin;OTTHUMP00000198195;OTTHUMP00000198196;OTTHUMP00000198197;CGI-56

Recombinant Proteins

  • Human
  • Zebrafish
  • E.coli
  • Mammalian Cell
  • HEK293
  • Mammalian cells
  • HEK293T
  • His
  • Non
  • Flag
  • His&Fc&Avi
  • Myc&DDK
Cat.# Product name Source (Host) Species Tag Protein Length Price
PARVB-3781H Recombinant Human PARVB protein, His-tagged E.coli Human His 1-364 aa
PARVB-10120Z Recombinant Zebrafish PARVB Mammalian Cell Zebrafish His
PARVB-3425HCL Recombinant Human PARVB 293 Cell Lysate HEK293 Human Non
PARVB-1249HFL Recombinant Full Length Human PARVB Protein, C-Flag-tagged Mammalian cells Human Flag Full L.
PARVB-1609H Recombinant Human PARVB Protein, His (Fc)-Avi-tagged HEK293 Human His&Fc&Avi
PARVB-1609H-B Recombinant Human PARVB Protein Pre-coupled Magnetic Beads HEK293 Human
PARVB-6240H Recombinant Human PARVB Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Human Myc&DDK

    Involved Pathway

    PARVB involved in several pathways and played different roles in them. We selected most pathways PARVB participated on our site, such as Cell junction organization,Cell-Cell communication,Cell-extracellular matrix interactions, which may be useful for your reference. Also, other proteins which involved in the same pathway with PARVB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Focal adhesion MAPK3,PIK3CB,PPP1R12C,FLNB,PXN,VASPA,SEPP1,PIK3R5,SHC3,CAV1
    Cell junction organization ANG,CDH7,PLEC,F11R.2,CLDN7,CDH10A,ITGB1B.1,CLDN20,CLDN16,DST
    Cell-extracellular matrix interactions RSU1,TESK1,ITGB1B.1,FBLIM1,LIMS1,FERMT2
    Regulation of cytoskeletal remodeling and cell spreading by IPP complex components LIMS1,TESK1,RSU1
    Cell-Cell communication CDH6,CDH3,CDH17,PLEC,CADM2B,CDH11,TESK1,DST,JUP,CLDN16

    Protein Function

    PARVB has several biochemical functions, for example, actin binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PARVB itself. We selected most functions PARVB had, and list some proteins which have the same functions with PARVB. You can find most of the proteins on our site.

    Function Related Protein
    actin binding HDAC6,ACTN3B,ACTR3B,ABLIM1A,MYOZ2,FKBP15,MYLK,TPMA,FMNL2,CNN3B
    protein binding TSPAN15,DDO,C16orf59,a,TTC12,FGD5,IL1RN,NRSN1,TNFAIP8L1,TNFRSF1A

    Interacting Protein

    PARVB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PARVB here. Most of them are supplied by our site. Hope this information will be useful for your research of PARVB.

    ILK;Arhgef7;Arhgef6;STK4;SNW1;CDC5L;Ilk

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