PARD3
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Official Full Name
par-3 partitioning defective 3 homolog (C. elegans) -
Overview
This gene encodes a member of the PARD protein family. PARD family members interact with other PARD family members and other proteins; they affect asymmetrical cell division and direct polarized cell growth. Multiple alternatively spliced transcript variants have been described for this gene. -
Synonyms
PARD3;par-3 partitioning defective 3 homolog (C. elegans);par 3 (partitioning defective 3, C.elegans) homolog;partitioning defective 3 homolog;ASIP;atypical PKC isotype specific interacting protein;Baz;Bazooka;PAR3;PARD3A;agouti signaling protein;CTCL tumor antigen se2-5;PAR3 alpha;Partitioning-defective 3 homolog;PARD-3;PAR3-alpha;OTTHUMP00000019427;OTTHUMP00000019428;OTTHUMP00000019429;OTTHUMP00000019430;OTTHUMP00000019431;OTTHUMP00000019432;OTTHUMP00000019434;OTTHUMP00000019435;atypical PKC isotype-specif;SE2-5T2;SE2-5L16;SE2-5LT1;PAR3alpha
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PARD3-11753Z | Recombinant Zebrafish PARD3 | Mammalian Cells | Zebrafish | His |
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| PARD3-3343C | Recombinant Chicken PARD3 | Mammalian Cells | Chicken | His |
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| PARD3-4270R | Recombinant Rat PARD3 Protein | Mammalian Cells | Rat | His |
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| PARD3-1283HCL | Recombinant Human PARD3 cell lysate | Human | Non |
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| PARD3-3932R | Recombinant Rat PARD3 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| PARD3-3932R-B | Recombinant Rat PARD3 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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Involved Pathway
PARD3 involved in several pathways and played different roles in them. We selected most pathways PARD3 participated on our site, such as Rap signaling pathway,Chemokine signaling pathway,Neuroactive ligand-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with PARD3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Chemokine signaling pathway | CCR8,CCL11,CXCL8,GNGT1,ARRB1,AMCF-II,Ccl9,PLCB3,SOS1,GNB4 |
| Rap signaling pathway | AKT1,CALM3,FGF16,ANGPT4,GNAQ,PIK3R1,RAP1B,TEK,MAP2K1,PRKCI |
| Hippo signaling pathway | TGFB2,ITGB2,FRMD6,WNT16,PPP2R2C,AREG,PPP1CB,WNT3,ACTG1,WNT10B |
| Endocytosis | RAB10,CAPZA1,MVB12A,CXCR4B,KIT,DNM2A,ARRB2A,SNX5,EHD1B,ITCH |
| Neuroactive ligand-receptor interaction | APLNR,ADRA1BB,LHBETA1,S1PR5A,NPBWR2,CHRNA3,NPBWR1,SSTR2,DRD4-RS,GRIA4B |
| Tight junction | SHROOM2,CLDN7,GNAIA,AKT2L,PARD6B,MYLPF,CLDNA,CLDN9,HRASA,ACTG1 |
| Adherens junction | IGF1R,RAC1,RAC3,PVRL1,FER,LMO7A,RAC3A,RAC1A,WASF3B,EGFR |
Protein Function
PARD3 has several biochemical functions, for example, phosphatidylinositol-3,4,5-trisphosphate binding,phosphatidylinositol-3-phosphate binding,phosphatidylinositol-4,5-bisphosphate binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PARD3 itself. We selected most functions PARD3 had, and list some proteins which have the same functions with PARD3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| phosphatidylinositol-3,4,5-trisphosphate binding | ASAP1,MYO1G,JPH2,ZFYVE16,BTK,PHLDA3,DAPP1,ANXA8,NRGN,PIRT |
| phosphatidylinositol-4,5-bisphosphate binding | SLC9A1,ANXA2,PFN2,RAB35,TULP3,RS1,KCNQ1,MYO1G,ADAP2,PFN1 |
| protein binding | ALKBH6,FAT4,NMRK2,TGFB2,NCOA2,STRA13,PEX19,PPP1R9A,TEAD4,HSPA4L |
| protein kinase C binding | DACT2,HDAC7A,SQSTM1,SDPRB,ADD3,HINT1,GLRX3,PRKCSH,PLEK,TRPV4 |
| protein phosphatase binding | PPP6R3,AP3B1,CSK,ANAPC5,JAK1,PIK3R2,EGFR,TRAF2,ROS1,CSF1R |
| phosphatidylinositol-3-phosphate binding | TECPR1,RS1,SNX21,SH3PXD2B,SNX13,SNX27,LANCL2,SNX24,WDR45,SESTD1 |
Interacting Protein
PARD3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PARD3 here. Most of them are supplied by our site. Hope this information will be useful for your research of PARD3.
PARD6A;YWHAB;YWHAZ;Pard6b;YWHAH
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