PAPPA2
-
Official Full Name
pappalysin 2 -
Overview
This gene encodes a member of the pappalysin family of metzincin metalloproteinases. The encoded protein cleaves insulin-like growth factor-binding protein 5 and is thought to be a local regulator of insulin-like growth factor (IGF) bioavailability. Alternative splicing results in multiple transcript variants. -
Synonyms
PAPPA2;pappalysin 2;PLAC3, placenta specific 3;pappalysin-2;PAPP A2;PAPPE;PAPP-E;placenta-specific 3;pregnancy-associated plasma protein E1;pregnancy-associated plasma preproprotein-A2;PLAC3;PAPP-A2
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PAPPA2-821H | Recombinant Human PAPPA2 protein(Ser234-Cys1396), His-tagged | HEK293 | Human | His | Ser234-Cys1396 | |
| PAPPA2-8058H | Recombinant Human PAPPA2 protein, His-tagged | E.coli | Human | His | Gly888~Ala1093 |
|
| PAPPA2-8059H | Recombinant Human PAPPA2 protein, His-tagged | E.coli | Human | His | His1309~Ser1492 |
|
| PAPPA2-2876HCL | Recombinant Human PAPPA2 cell lysate | Human Cell | Human | Non |
|
|
| CABT-36184MH | Mouse Anti-Human PAPPA2 Monoclonal Antibody | Mouse | Human | Non |
|
|
| PAPPA2-5071H | Recombinant Human PAPPA2 Protein (Ser234-Cys1396), N-His tagged | E.coli | Human | His | Ser234-Cys1396 |
|
Involved Pathway
PAPPA2 involved in several pathways and played different roles in them. We selected most pathways PAPPA2 participated on our site, such as Metabolism of proteins,Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), which may be useful for your reference. Also, other proteins which involved in the same pathway with PAPPA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolism of proteins | LMAN2L,FKBP9,PHC2,DDOST,IGFBP6A,GPR120,DAD1,INHBAA,NAPAA,TBCC |
| Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) | GZMH,PAPPA,IGFALS,IGFBP5,IGFBP4,KLK13,IGFBP2A,IGFBP6A,IGFBP2B,PAPPAB |
Protein Function
PAPPA2 has several biochemical functions, for example, metallopeptidase activity,zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PAPPA2 itself. We selected most functions PAPPA2 had, and list some proteins which have the same functions with PAPPA2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| zinc ion binding | NEURL1B,USP33,MICAL2B,ZCCHC9,HDAC6,RORA,PHF17,RNF183,CAR3,MYLIPA |
| metallopeptidase activity | ADAM30,C6AST3,ACE,DPEP3,STAMBPL1,YME1L1,AFG3L2,ADAM8,PAPPAB,ADAM17 |
Interacting Protein
PAPPA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PAPPA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PAPPA2.
SMAD4;ATF7IP;ZNF512B
Resources
Related Services
Related Products
References
