PAG1

  • Official Full Name

    phosphoprotein associated with glycosphingolipid microdomains 1

  • Overview

    Cyclic AMP-regulated gene expression frequently involves a DNA element designated the cAMP-regulated enhancer (CRE). Many transcription factors, including the protein CREB, which is activated as a result of phosphorylation by protein kinase A, bind to this element. It has been shown that protein kinase A-mediated CREB phosphorylation results in its binding to a 265 kDa nuclear protein designated CBP (for CREB-binding protein). These findings suggest that CBP has many of the properties expected of a CREB co-activator. Another high molecular weight transcriptional adapter protein, designated p300, is characterized by three cysteine- and histidine-rich regions, of which the most carboxy terminal region specifically binds the adenovirus E1A protein. p300 molecules lacking an intact E1A binding site bypass E1A repression even in the presence of high concentrations of E1A. Sequence analysis of CBP and p300 has revealed substantial homology, arguing that these proteins are members of a conserved family of co-activators.

  • Synonyms

    PAG1;phosphoprotein associated with glycosphingolipid microdomains 1;phosphoprotein associated with glycosphingolipid-enriched microdomains 1;CBP;Csk binding protein;PAG;transmembrane adaptor protein PAG;Csk-binding protein;transmembrane phosphoprotein Cbp;transmembrane adapter protein PAG;FLJ37858;MGC138364
Cat.# Product name Source (Host) Species Tag Protein Length Price
Pag1-521M Recombinant Mouse Pag1 Protein, His-tagged E.coli Mouse His Gly160~Gln390
Pag1-522R Recombinant Rat Pag1 Protein, His-tagged E.coli Rat His Ile138~Phe357
PAG1-30060TH Recombinant Human PAG1, His-tagged E.coli Human His
PAG1-3465HCL Recombinant Human PAG1 293 Cell Lysate HEK293 Human Non
PAG1-0031B Recombinant Bovine PAG1 Protein (Arg54-Val380), N-His-tagged E.coli Bovine His Arg54-Val380

    Involved Pathway

    PAG1 involved in several pathways and played different roles in them. We selected most pathways PAG1 participated on our site, such as Adaptive Immune System,BCR signaling pathway,CXCR4-mediated signaling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with PAG1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Signal Transduction NPS,STRAP,WLS,SCT,QRFPR,ARAP2,RHPN2,OTULIN,CBY1,RBCK1
    Signaling by EGFR ADAM12,PTPRK,SPRY1,LRIG1
    Adaptive Immune System MGC174857,TREM1,CD226,LRRC41,PPIAL4A,SIGLEC8,AP2S1,CLEC2G,ERAP1,PDPK1A
    Immune System ASB11,TRIM10,POLR3G,CD207,MASP2,FBXO3,TRIM62,EGR1,HUWE1,DEFB119
    CXCR4-mediated signaling events ARR3,CFL1,GNB2L1,MAPKAP1,GNA13,BLK,CSK,DNM1,JAK2,ADRBK1
    BCR signaling pathway CSK,MALT1,DOK1,POU2F2,MAP4K1,IBTK,CSNK2A1,NETO2

    Protein Function

    PAG1 has several biochemical functions, for example, SH2 domain binding,SH3/SH2 adaptor activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PAG1 itself. We selected most functions PAG1 had, and list some proteins which have the same functions with PAG1. You can find most of the proteins on our site.

    Function Related Protein
    SH3/SH2 adaptor activity GRAP,STAP1,SRC,GAB1,SH3BGR,SLA,SH2D3A,HSH2D,BLNK,SH2D2A
    protein binding AIMP2,ANP32B,MAPKAP1,FAM86C,XAGE3,PLEKHG4,DDI1,PLEKHF1,CYB561,SRSF11
    SH2 domain binding LAX1,GNB2L1,LAT2,LILRB1,NLK,DLC1,CRK,SIT1,DAG1,TRPV4

    Interacting Protein

    PAG1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PAG1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PAG1.

    FYN;SLC9A3R1;LYN;EGFR;PRKCB;GNB2L1;ppaC;CSK

    Resources

    Research Area

    Mast Cells

    References

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