PACRG

  • Official Full Name

    PARK2 co-regulated

  • Overview

    This gene encodes a protein that is conserved across metazoans. In vertebrates, this gene is linked in a head-to-head arrangement with the adjacent parkin gene, which is associated with autosomal recessive juvenile Parkinsons disease. These genes are co-regulated in various tissues and they share a bi-directional promoter. Both genes are associated with susceptibility to leprosy. The parkin co-regulated gene protein forms a large molecular complex with chaperones, including heat shock proteins 70 and 90, and chaperonin components. This protein is also a component of Lewy bodies in Parkinsons disease patients, and it suppresses unfolded Pael receptor-induced neuronal cell death. Multiple transcript variants encoding different isoforms have been found for this gene.

  • Synonyms

    PACRG;PARK2 co-regulated;parkin coregulated gene protein;FLJ32724;Glup;HAK005771;PARK2CRG;Molecular chaperone/chaperonin binding protein;PARK 2 co regulated;PARK 2 coregulated;PARK2 co regulated;PARK2 coregulated;Parkin co regulated gene;Parkin co regulated gene protein;Parkin coregulated gene;RP3 495O10.2;parkin co-regulated gene protein;molecular chaperone/chaperonin-binding protein;RP3-495O10.2

Recombinant Proteins

  • Zebrafish
  • Rhesus macaque
  • Human
  • Mouse
  • Mammalian Cell
  • HEK293
  • HEK293T
  • His
  • Non
  • His&Fc&Avi
  • Myc&DDK
Cat.# Product name Source (Host) Species Tag Protein Length Price
PACRG-1782Z Recombinant Zebrafish PACRG Mammalian Cell Zebrafish His
PACRG-3279R Recombinant Rhesus monkey PACRG Protein, His-tagged Mammalian Cell Rhesus macaque His
PACRG-3474HCL Recombinant Human PACRG 293 Cell Lysate HEK293 Human Non
PACRG-3475HCL Recombinant Human PACRG 293 Cell Lysate HEK293 Human Non
PACRG-3097R Recombinant Rhesus Macaque PACRG Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque His&Fc&Avi
PACRG-3097R-B Recombinant Rhesus Macaque PACRG Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
Pacrg-4646M Recombinant Mouse Pacrg Protein, Myc/DDK-tagged HEK293T Mouse Myc&DDK
PACRG-6267H Recombinant Human PACRG Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Human Myc&DDK

    Involved Pathway

    PACRG involved in several pathways and played different roles in them. We selected most pathways PACRG participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PACRG were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein

    Protein Function

    PACRG has several biochemical functions, for example, G-protein coupled receptor binding,Hsp70 protein binding,Hsp90 protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PACRG itself. We selected most functions PACRG had, and list some proteins which have the same functions with PACRG. You can find most of the proteins on our site.

    Function Related Protein
    chaperone binding C1orf182,HSP104,GNB5,ATP1A3,SERPINA7,DNAJC10,SLC25A17,HSCB,RNF207,BAG1
    G-protein coupled receptor binding NPB,FYN,PROK1,GNA15.4,PYY,CORT,HSPA8,SFTPBB,SAA1,GNAI2
    beta-tubulin binding NDEL1,CCT5,SPAST,TRPV4,EMD,UXT,RACGAP1,SIRT2,AKAP1,RANBP10
    heat shock protein binding DNAJC7,FKBP5,LMAN2,PPID,TOMM34,DNAJA3A,NFKB1,HSPA1A,DAXX,IRAK1
    Hsp70 protein binding CDKN1B,CDK1,DNAJC10,STUB1,TFRC,ERN1,BAG6,PPEF2,DNAJB1,RNF207
    ubiquitin protein ligase binding CDKN1A,UBXN1,AMBRA1,ATXN3,CASP8,NDUFS2,ERBB2,VCP,FOXO1,ASB4
    alpha-tubulin binding NDEL1,TRPV4,SLC6A2,B4GALT1,CAV3,FAM110C,SPAST,SNCA,BBS4,ARL4C
    actin binding PLEKHH2,ACTN3A,MYO5C,FRG1,S100A4,SSH1,DIAP1,SPTBN2,NRAP,SPIRE1
    Hsp90 protein binding EIF2AK3,AHR,ERBB2,RPS3,ERN1,CDC37,PPID,USP19,HDAC6,CHORDC1

    Interacting Protein

    PACRG has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PACRG here. Most of them are supplied by our site. Hope this information will be useful for your research of PACRG.

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