P4HA2

  • Official Full Name

    prolyl 4-hydroxylase, alpha polypeptide II

  • Overview

    This gene encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one of several different types of alpha subunits and provides the major part of the catalytic site of the active enzyme. In collagen and related proteins, prolyl 4-hydroxylase catalyzes the formation of 4-hydroxyproline that is essential to the proper three-dimensional folding of newly synthesized procollagen chains. Alternatively spliced transcript variants encoding different isoforms have been described.

  • Synonyms

    P4HA2;prolyl 4-hydroxylase, alpha polypeptide II;procollagen proline, 2 oxoglutarate 4 dioxygenase (proline 4 hydroxylase), alpha polypeptide II;prolyl 4-hydroxylase subunit alpha-2;4 PH alpha 2;C P4Halpha(II);collagen prolyl 4 hydroxylase alpha(II);2-oxoglutarate-4-dioxygenase subunit alpha-2;4-PH alpha-2;P4HA2_HUMAN;Procollagen-proline;Prolyl 4 hydroxylase alpha 2 subunit;Prolyl 4 hydroxylase subunit alpha 2 [Precursor];4-PH alpha 2;C-P4Halpha(II);collagen prolyl 4-hydroxylase alpha(II);procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-2;procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide II

Recombinant Proteins

  • Human
  • Chicken
  • Zebrafish
  • Rhesus macaque
  • Mouse
  • E.coli
  • Mammalian Cells
  • HEK293
  • His&T7
  • His
  • Non
  • Myc&DDK
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
P4HA2-1178H Recombinant Human P4HA2 protein, His & T7-tagged E.coli Human His&T7 Ser207~Glu520
P4HA2-1307C Recombinant Chicken P4HA2 Mammalian Cells Chicken His
P4HA2-1680Z Recombinant Zebrafish P4HA2 Mammalian Cells Zebrafish His
P4HA2-3274R Recombinant Rhesus monkey P4HA2 Protein, His-tagged Mammalian Cells Rhesus macaque His
P4HA2-3481HCL Recombinant Human P4HA2 293 Cell Lysate HEK293 Human Non
P4HA2-1578H Recombinant Human P4HA2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293 Human Myc&DDK
P4HA2-3092R Recombinant Rhesus Macaque P4HA2 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque His&Fc&Avi
P4HA2-3092R-B Recombinant Rhesus Macaque P4HA2 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
P4ha2-4641M Recombinant Mouse P4ha2 Protein, Myc/DDK-tagged HEK293 Mouse Myc&DDK
P4HA2-5266H Recombinant Human P4HA2 Protein (Ser207-Glu520), N-His tagged E.coli Human His Ser207-Glu520

    Involved Pathway

    P4HA2 involved in several pathways and played different roles in them. We selected most pathways P4HA2 participated on our site, such as Arginine and proline metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with P4HA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Arginine and proline metabolism ODC1,GAMT,NOS2A,CKMA,P4HA3,MAOB,DAO.3,ALDH2.2,AGMAT,CARNS1
    Metabolic pathways ME3,NDUFB1,HIBCH,EXT1,ATP6V0C,PIK3C2G,CKMT2B,UGT5G1,B4GALNT1,PIGK

    Protein Function

    P4HA2 has several biochemical functions, for example, L-ascorbic acid binding,electron carrier activity,iron ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by P4HA2 itself. We selected most functions P4HA2 had, and list some proteins which have the same functions with P4HA2. You can find most of the proteins on our site.

    Function Related Protein
    L-ascorbic acid binding LEPREL1,LEPRE1,P4HA1A,OGFOD1,OGFOD3,PLOD3,PHYH,P3H2,P4HA1B,P4HA1
    protein binding ITGB1,NXF3,ARHGEF38,FOSL1,SMU1,GH1,NFYC,VLDLR,SPOPL,OSTB
    iron ion binding CYP1A1,OGFOD2,CYP4V7,CYP2C39,HBG1,CYP3A25,CYP46A1.3,BBOX1,ALOX12,CYP1C2
    electron carrier activity PTGES2,FDX1B,COX7A1,COX11,AKR1C4,ACAD11,ACADSB,CYP1A2,AKR1A1,NCF2
    oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX12,P4HA3,ALOX5A,P4HA1B,ADOB,P4HA1A,ALOX5B.2,ALOX8,ADOA,ALOX12E
    procollagen-proline 4-dioxygenase activity P4HA1A,P4HA3,P4HA1,P4HA1B

    Interacting Protein

    P4HA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with P4HA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of P4HA2.

    DMWD;CREB3;PRRC2A;IRS4;cona_canen;env;H2AFX;EBNA-LP

    Resources

    Research Area

    ECM Regulators

    References

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