OSGIN1
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Official Full Name
oxidative stress induced growth inhibitor 1 -
Overview
This gene encodes an oxidative stress response protein that regulates cell death. Expression of the gene is regulated by p53 and is induced by DNA damage. The protein regulates apoptosis by inducing cytochrome c release from mitochondria. It also appears to be a key regulator of both inflammatory and anti-inflammatory molecules. The loss of this protein correlates with uncontrolled cell growth and tumor formation. Naturally occurring read-through transcription exists between this gene and the neighboring upstream malonyl-CoA decarboxylase (MLYCD) gene, but the read-through transcripts are unlikely to produce a protein product. -
Synonyms
OSGIN1;oxidative stress induced growth inhibitor 1;oxidative stress-induced growth inhibitor 1;BDGI;bone marrow stromal cell derived growth inhibitor;OKL38;pregnancy induced growth inhibitor;1700012B18Rik;huOKL38;OKL 38;OSGIN 1;OTTHUMP00000174992;OTTHUMP00000174993;Ovary kidney and liver protein 38;Pregnancy induced growth inhibitor OKL38;ovary, kidney and liver protein 38;pregnancy-induced growth inhibitor OKL38;bone marrow stromal cell-derived growth inhibitor
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| OSGIN1-409H | Recombinant Human OSGIN1 Protein, His-tagged | E.coli | Human | His | Gly25~Val281 | |
| OSGIN1-911H | Recombinant Human OSGIN1, His-tagged | E.coli | Human | His | 1-560 a.a. |
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| OSGIN1-1247HCL | Recombinant Human OSGIN1 cell lysate | Human | Non |
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| OSGIN1-1723H | Recombinant Human OSGIN1 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
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| Osgin1-4618M | Recombinant Mouse Osgin1 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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Involved Pathway
OSGIN1 involved in several pathways and played different roles in them. We selected most pathways OSGIN1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with OSGIN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
OSGIN1 has several biochemical functions, for example, growth factor activity,oxidoreductase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by OSGIN1 itself. We selected most functions OSGIN1 had, and list some proteins which have the same functions with OSGIN1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| oxidoreductase activity | CYP8B3,CYP2C50,CYP4A12A,SC4MOL,SDR39U1,CYP2AD3,TDO2B,CBR2,SDR16C5B,CYP2C54 |
| protein binding | LOXL2,NSMAF,OAS2,CCT6A,CEP68,ZNHIT1,TUB,HIST1H4F,RPUSD3,GPR37 |
| growth factor activity | OGN,TDGF1,MDKA,LACRT,NDP,TGFB1,VHL,THBS4B,TGFB2,FIGF |
Interacting Protein
OSGIN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with OSGIN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of OSGIN1.
MEOX2;80125;MEIS2;CRX;TCF4;CAPN3;REL
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References
- He, W; Zhang, J; et al. Advanced Glycation End Products Induce Endothelial-to-Mesenchymal Transition via Downregulating Sirt 1 and Upregulating TGF-beta in Human Endothelial Cells. BIOMED RESEARCH INTERNATIONAL :-(2015).
- Lu, GH; Xu, S; et al. Angiotensin II upregulates Kv1.5 expression through ROS-dependent transforming growth factor-beta1 and extracellular signal-regulated kinase 1/2 signalings in neonatal rat atrial myocytes. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 454:410-416(2014).
