ORAI1

  • Official Full Name

    ORAI calcium release-activated calcium modulator 1
  • Overview

    The protein encoded by this gene is a membrane calcium channel subunit that is activated by the calcium sensor STIM1 when calcium stores are depleted. This type of channel is the primary way for calcium influx into T-cells. Defects in this gene are a cause of immune dysfunction with T-cell inactivation due to calcium entry defect type 1 (IDTICED1).
  • Synonyms

    ORAI1;ORAI calcium release-activated calcium modulator 1;TMEM142A, transmembrane protein 142A;calcium release-activated calcium channel protein 1;calcium release activated calcium modulator 1;CRACM1;FLJ14466;protein orai-1;transmembrane protein 1

Recombinant Proteins

  • Human
  • Chicken
  • Rat
  • Xenopus laevis
  • Mus musculus
  • zebrafish
  • E.coli
  • Mammalian Cell
  • HEK293
  • E.coli expression system
  • His
  • GST
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
ORAI1-3265H Recombinant Human ORAI1 protein, His-tagged E.coli Human His 1-75 aa
ORAI1-2364C Recombinant Chicken ORAI1 Mammalian Cell Chicken His
ORAI1-4198R Recombinant Rat ORAI1 Protein Mammalian Cell Rat His
ORAI1-981H Recombinant Human ORAI1 Mammalian Cell Human His
ORAI1-301514H Recombinant Human ORAI1 protein, GST-tagged E.coli Human GST Met1-Ser75
ORAI1-3767H Recombinant Human ORAI1 Protein, His (Fc)-Avi-tagged HEK293 Human His&Fc&Avi
ORAI1-3767H-B Recombinant Human ORAI1 Protein Pre-coupled Magnetic Beads HEK293 Human
ORAI1-3860R Recombinant Rat ORAI1 Protein, His (Fc)-Avi-tagged HEK293 Rat His&Fc&Avi
ORAI1-3860R-B Recombinant Rat ORAI1 Protein Pre-coupled Magnetic Beads HEK293 Rat
RFL10144HF Recombinant Full Length Human Calcium Release-Activated Calcium Channel Protein 1(Orai1) Protein, His-Tagged E.coli expression system Human His Full L. Full Length (1-301)
RFL29240XF Recombinant Full Length Xenopus Laevis Calcium Release-Activated Calcium Channel Protein 1(Orai1) Protein, His-Tagged E.coli expression system Xenopus laevis His Full L. Full Length (1-258)
RFL29944GF Recombinant Full Length Chicken Calcium Release-Activated Calcium Channel Protein 1(Orai1) Protein, His-Tagged E.coli expression system Chicken His Full L. Full Length (1-226)
RFL513MF Recombinant Full Length Mouse Calcium Release-Activated Calcium Channel Protein 1(Orai1) Protein, His-Tagged E.coli expression system Mus musculus His Full L. Full Length (1-304)
RFL6491RF Recombinant Full Length Rat Calcium Release-Activated Calcium Channel Protein 1(Orai1) Protein, His-Tagged E.coli expression system Rat His Full L. Full Length (1-304)
RFL7216DF Recombinant Full Length Danio Rerio Calcium Release-Activated Calcium Channel Protein 1(Orai1) Protein, His-Tagged E.coli expression system zebrafish His Full L. Full Length (1-222)

    Involved Pathway

    ORAI1 involved in several pathways and played different roles in them. We selected most pathways ORAI1 participated on our site, such as Calcium signaling pathway,cAMP signaling pathway,Platelet activation, which may be useful for your reference. Also, other proteins which involved in the same pathway with ORAI1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Primary i Cd79a,IL2RG,TAP1,CD4,TNFRSF13B,DCLRE1C,RAG2,CD19,CD3D,BLNK
    Renin secretion CLCA5,CALM4,PPP3R1,PLCB3,CALM1,LOC100328615,PTGER4,PDE1C,PLCB1,GNAS
    Aldosterone synthesis and secretion AGTR1,PLCB1,PRKACA,ATF1,CYP21A2,AGTR1B,CREB3L2,NETO2,CAMK1,ADCY3
    cAMP signaling pathway RAC2,CALM1,GIPR,PLCE1,RAP1B,RAC1,RELA,ACOX3,HHIP,HTR1B
    nodeficiency CD8B1,CD8B,TAP2,UNG,BLNK,IL2RG,IL7R,IKBKG,ZAP70,AICDA
    Platelet activation FERMT3,PPP1CB,SRC,PLCG2,VWF,MYLK4,P2RY12,GP5,F2R,ARHGEF1
    Calcium signaling pathway ERBB2,ITPR3,CALM4,TACR1A,ADCY2B,AKR1C1,PLCD3A,VDAC1,HTR6,ITPKA

    Protein Function

    ORAI1 has several biochemical functions, for example, calmodulin binding,identical protein binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ORAI1 itself. We selected most functions ORAI1 had, and list some proteins which have the same functions with ORAI1. You can find most of the proteins on our site.

    Function Related Protein
    calmodulin binding TRPM4,SCN5A,PHKA2,ITPKC,RGS4,MAPKAPK2B,CALD1B,MARCKSL1,MYH4,MAP6
    store-operated calcium channel activity STIM2,TRPC7A,TRPC2B,TRPC6A,TRPC6,TRPC4,ORAI2,TRPC1,ORAI1B,TRPC5A
    protein binding RUSC2,ID4,ETL4,MIF4GD,WWC1,PSEN2,BLCAP,SULT2A1,DYNAP,LRP12
    identical protein binding SH3GL3,AIRE,GCG,UGP2,SMG9,RASSF1,PICK1,SNX33,STIM1,PYDC3

    Interacting Protein

    ORAI1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ORAI1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ORAI1.

    STIM1;ATP2C2

    Resources

    References

    • Gaida, K; Salimi-Moosavi, H; et al. Inhibition of CRAC with a human anti-ORAI1 monoclonal antibody inhibits T-cell-derived cytokine production but fails to inhibit a T-cell-dependent antibody response in the cynomolgus monkey. JOURNAL OF IMMUNOTOXICOLOGY 12:164-173(2015).
    • Guzman, R; Valente, EG; et al. Expression of ORAI1, a Plasma Membrane Resident Subunit of the CRAC Channel, in Rodent and Non-rodent Species. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY 62:864-878(2014).

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