OGFR
-
Official Full Name
opioid growth factor receptor -
Overview
The protein encoded by this gene is a receptor for opioid growth factor (OGF), also known as (Met(5))-enkephalin. OGF;is a negative regulator of cell proliferation and tissue organization in a variety of processes. The encoded unbound;receptor for OGF has been localized to the outer nuclear envelope, where it binds OGF and is translocated into the;nucleus. The coding sequence of this gene contains a polymorphic region of 60 nt tandem imperfect repeat units.;Several transcripts containing between zero and eight repeat units have been reported. -
Synonyms
OGFR;opioid growth factor receptor;7 60;7-60 protein;protein 7-60;zeta-type opioid receptor
Recombinant Proteins
- Mouse
- Human
- Mammalian Cell
- E.coli
- HEK293
- HEK293T
- Mammalian cells
- His
- Non
- Myc&DDK
- His&Fc&Avi
- Flag
- His&Myc
Involved Pathway
OGFR involved in several pathways and played different roles in them. We selected most pathways OGFR participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with OGFR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
OGFR has several biochemical functions, for example, opioid receptor activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by OGFR itself. We selected most functions OGFR had, and list some proteins which have the same functions with OGFR. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | TFDP2,RBM41,AP2A1,MCM4,TRAF3IP2,RBM44,PEX10,FAM21C,CAMK2G,SAP18 |
| opioid receptor activity | OPRD1,SIGMAR1,NPBWR2,OPRD1B,OPRK1,OPRD1A,NPBWR1 |
Interacting Protein
OGFR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with OGFR here. Most of them are supplied by our site. Hope this information will be useful for your research of OGFR.
TERF2IP;GSTK1;TERF1
Resources
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References
- Zagon, IS; Porterfield, NK; et al. Opioid growth factor - opioid growth factor receptor axis inhibits proliferation of triple negative breast cancer. EXPERIMENTAL BIOLOGY AND MEDICINE 238:589-599(2013).
- Campbell, AM; Zagon, IS; et al. Astrocyte proliferation is regulated by the OGF-OGFr axis in vitro and in experimental autoimmune encephalomyelitis. BRAIN RESEARCH BULLETIN 90:43-51(2013).
