OGDH
-
Official Full Name
oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) -
Overview
This gene encodes one subunit of the 2-oxoglutarate dehydrogenase complex. This complex catalyzes the overall conversion of 2-oxoglutarate (alpha-ketoglutarate) to succinyl-CoA and CO(2) during the Krebs cycle. The protein is located in the mitochondrial matrix and uses thiamine pyrophosphate as a cofactor. A congenital deficiency in 2-oxoglutarate dehydrogenase activity is believed to lead to hypotonia, metabolic acidosis, and hyperlactatemia. Alternative splicing results in multiple transcript variants encoding distinct isoforms. -
Synonyms
OGDH;oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide);2-oxoglutarate dehydrogenase, mitochondrial;E1k;OGDC-E1;oxoglutarate decarboxylase;2-oxoglutarate dehydrogenase complex component E1;oxoglutarate dehydrogenase (succinyl-transferring
Recombinant Proteins
- Human
- Mouse
- Chicken
- Rat
- E.coli
- Mammalian Cell
- HEK293
- Mamanlian cells
- HEK293T
- GST
- His
- Myc&DDK
- Non
- His&SUMO
- Flag
- His&Fc&Avi
Involved Pathway
OGDH involved in several pathways and played different roles in them. We selected most pathways OGDH participated on our site, such as Citrate cycle (TCA cycle),Lysine degradation,Tryptophan metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with OGDH were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Tryptophan metabolism | KYNU,IDO1,GCDH,MAOB,AOX1,ALDH2,KMO,HADHA,CCBL1,ALDH9A1A.1 |
| Metabolic pathways | RPN1,UGT1A6B,RDH8B,POLR2G,CYP2P7,FUK,ALDOA,IDO1,POLE4,PGP |
| Lysine degradation | SUV39H1B,HADHA,SETDB2,EHHADH,MLL5,BBOX1,CAMKMT,ALDH2.2,ACAT1,DLST |
| Citrate cycle (TCA cycle) | PDHA1,MDH1,IDH1,ACLYA,DLDH,SDHA,SDHD,PDHA1B,IDH3B,PDHB |
| Carbon metabolism | PGP,ALDOC,TKTL1,PGD,DAK,TALDO1,GPIA,FBP1A,HK2,ADPGK |
Protein Function
OGDH has several biochemical functions, for example, metal ion binding,oxoglutarate dehydrogenase (NAD+) activity,oxoglutarate dehydrogenase (succinyl-transferring) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by OGDH itself. We selected most functions OGDH had, and list some proteins which have the same functions with OGDH. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| oxoglutarate dehydrogenase (succinyl-transferring) activity | OGDHA,DHTKD1 |
| thiamine pyrophosphate binding | ILVBL,OGDHA,HACL1,DHTKD1 |
| metal ion binding | FTR43,PDE8A,NGB,GIT2,RFPL4,ZBTB12,SALL2,ZFP64,GM9524,ZNF597 |
Interacting Protein
OGDH has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with OGDH here. Most of them are supplied by our site. Hope this information will be useful for your research of OGDH.
USP13;PLSCR1;mtlR;lutA2;hflX;gph;15-deoxy-delta(12,14;ssdna_da;CAPZA2;SUMO3;ESR2;HDAC6;SIRT4
Resources
Related Services
Related Products
References
- Nemeria, NS; Ambrus, A; et al. Human 2-Oxoglutarate Dehydrogenase Complex E1 Component Forms a Thiamin-derived Radical by Aerobic Oxidation of the Enamine Intermediate. JOURNAL OF BIOLOGICAL CHEMISTRY 289:29859-29873(2014).
- Starkov, AA; et al. An update on the role of mitochondrial alpha-ketoglutarate dehydrogenase in oxidative stress. MOLECULAR AND CELLULAR NEUROSCIENCE 55:13-16(2013).
