OBFC1
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Official Full Name
oligonucleotide/oligosaccharide-binding fold containing 1 -
Overview
OBFC1 and C17ORF68 (MIM 613129) are subunits of an alpha accessory factor (AAF) that stimulates the activity of DNA;polymerase-alpha-primase (see MIM 176636), the enzyme that initiates DNA replication (Casteel et al., 2009 (PubMed;19119139)). OBFC1 also appears to function in a telomere-associated complex with C17ORF68 and TEN1 (C17ORF106; MIM;613130) (Miyake et al., 2009 (PubMed 19854130)). -
Synonyms
OBFC1;oligonucleotide/oligosaccharide-binding fold containing 1;CST complex subunit STN1;bA541N10.2;FLJ22559;alpha accessory factor 44;suppressor of cdc thirteen homolog;replication protein A 32 kDa subunit;oligonucleotide/oligosaccharide-binding
Recombinant Proteins
- Zebrafish
- Mouse
- Human
- Rhesus macaque
- Rat
- Cynomolgus
- Mammalian Cell
- E.coli
- HEK293
- His
- Non
- His&Fc&Avi
Involved Pathway
OBFC1 involved in several pathways and played different roles in them. We selected most pathways OBFC1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with OBFC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
OBFC1 has several biochemical functions, for example, protein binding,single-stranded DNA binding,single-stranded telomeric DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by OBFC1 itself. We selected most functions OBFC1 had, and list some proteins which have the same functions with OBFC1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| contributes_to telomerase inhibitor activity | CDAN1,TEN1,CTC1 |
| single-stranded DNA binding | DMC1,MCM4,ERCC4,MCM6,XPC,RAD51L1,OBFC2B,RAD51B,CDC45,CNBP |
| protein binding | TEX11,KREMEN1,GLI3,PCSK9,DHX9,NOTCH1,TRAPPC6A,CCK,POU5F1,PDGFA |
| single-stranded telomeric DNA binding | POT1,POT1A,HNRNPA2B1 |
| telomeric DNA binding | TERT,POT1A,CDAN1,SMG6,TINF2,CTC1,TEN1,TERF2,NCL,HNRNPD |
Interacting Protein
OBFC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with OBFC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of OBFC1.
CTC1;telg31;LDLRAP1;TEN1;ACD;ZDHHC17;TUBGCP4
Resources
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References
- Raffa, GD; Raimondo, D; et al. Verrocchio, a Drosophila OB fold-containing protein, is a component of the terminin telomere-capping complex. GENES & DEVELOPMENT 24:1596-1601(2010).
- Choubey, D; Duan, X; et al. Interferon-Inducible p200-Family Proteins as Novel Sensors of Cytoplasmic DNA: Role in Inflammation and Autoimmunity. JOURNAL OF INTERFERON AND CYTOKINE RESEARCH 30:371-380(2010).
