Nkx2
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Official Full Name
NK2 transcription factor related, locus 9 (Drosophila)
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|
Involved Pathway
Nkx2 involved in several pathways and played different roles in them. We selected most pathways Nkx2 participated on our site, such as Cardiac Progenitor Differentiation,Gene Expression,Generic Transcription Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Nkx2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Generic Transcription Pathway | RARAA,ZNF311,ZNF436,CDK9,ZKSCAN4,ZNF658,NR1D2,ZNF692,ZNF559,KRBOX4 |
| Heart Development | TBX20,IRX4,BMP10,TBX5,FOXC2,NKX2-5,FOXC1,SMYD1,GATA6,HEY1 |
| Gene Expression | TEAD1A,ASZ1,EFCAB11,COX8A,ZNF155,ZNF222,VDRB,ZNF184,SCO1,GPR19 |
| Regulation of nuclear SMAD2/3 signaling | FOXH1,CITED1,MYOD1,CBFB,SNIP1,SKI,GSC |
| SRF and miRs in Smooth Muscle Differentiation and Proliferation | MEF2B |
| YAP1- and WWTR1 (TAZ)-stimulated gene expression | TEAD3B,HIPK1,TEAD1A,TBX5,TBX5A |
| Cardiac Progenitor Differentiation | SOX1,LIN28B,IRX4,ZFP42,NIPAL1,ROR2,LIN28A,BMP1,TBX20,T |
Protein Function
Nkx2 has several biochemical functions, for example, DNA binding,RNA polymerase II core promoter proximal region sequence-specific DNA binding,RNA polymerase II transcription cofactor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Nkx2 itself. We selected most functions Nkx2 had, and list some proteins which have the same functions with Nkx2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| chromatin binding | UBTF,GATA3,HMGB1A,SREBF1,MLH3,ATAD2B,SIRT2,CBX5,NPM2,CHD8 |
| transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding | NR5A2,HIF1A,NR5A1,NR1H4,OLIG2,MEIS1,FOXF2A,MEF2A,BHLHE40,SNAI2 |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | ZNF713,IFI203,NEUROG3,ATOH1,NRL,NR3C1,KCNA3,TLX1,HAND1,ZNF395 |
| contributes_to transcription factor activity, sequence-specific DNA binding | SOX19B,SMAD4,GATA4,TAF10,MAFGB,SOX1A,TAF7,RXRA,TRIM28,NKX2-5 |
| DNA binding | PIAS2,POLR2B,HMGA1A,GCM1,VPS72,DMBX1B,AHRRB,ZFP93,HMGB2B,C1D |
| RNA polymerase II transcription cofactor activity | MED11,MED12,CRSP7,MED19,MED19B,MED19A,MED1,MED15,MED30,PPARGC1A |
| transcription regulatory region DNA binding | GATA4,CREB3L1,SFPQ,SMAD7,TAF2,ZFP639,H2AFY,SALL1,ARID5B,IKZF3 |
| transcriptional activator activity, RNA polymerase II transcription factor binding | MIXL1,KLF4,NR1H4,NOTCH1,CREB1,NFE2L1,PPARA,JUN,LMO2,CLOCK |
| serum response element binding | SRF,NKX2-5 |
Interacting Protein
Nkx2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Nkx2 here. Most of them are supplied by our site. Hope this information will be useful for your research of Nkx2.
TBX5;afn promoter;CAMTA2
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