NUP214
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Official Full Name
nucleoporin 214kDa -
Overview
The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. This gene is a member of the FG-repeat-containing nucleoporins. The protein encoded by this gene is localized to the cytoplasmic face of the nuclear pore complex where it is required for proper cell cycle progression and nucleocytoplasmic transport. The 3 portion of this gene forms a fusion gene with the DEK gene on chromosome 6 in a t(6,9) translocation associated with acute myeloid leukemia and myelodysplastic syndrome. -
Synonyms
NUP214;nucleoporin 214kDa;nucleoporin 214kD (CAIN);nuclear pore complex protein Nup214;CAIN;CAN;CAN protein;putative oncogene;D9S46E;N214;214 kDa nucleoporin;NU214_HUMAN;Nucleoporin Nup214;Protein CAN;p250;CAN protein, putative oncogene
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| NUP214-10994M | Recombinant Mouse NUP214 Protein | Mammalian Cell | Mouse | His |
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| Nup214-1563M | Recombinant Mouse Nup214 protein, His & T7-tagged | E.coli | Mouse | His&T7 | Ser601~Arg868 |
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| NUP214-6271M | Recombinant Mouse NUP214 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| NUP214-6271M-B | Recombinant Mouse NUP214 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
NUP214 involved in several pathways and played different roles in them. We selected most pathways NUP214 participated on our site, such as RNA transport,Epstein-Barr virus infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with NUP214 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Epstein-Barr virus infection | NFKB1,POLR2J3,POLR2E,TAB2,POLR2H,SFPI1,HSPB1,HSPB2,STAT3,HLA-B |
| RNA transport | ELAC2,SUMO2B,EIF1AY,RPP25,EIF4BB,EIF4A3,UPF3A,SMN,TACC3,NCBP1 |
Protein Function
NUP214 has several biochemical functions, for example, nuclear localization sequence binding,nucleocytoplasmic transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NUP214 itself. We selected most functions NUP214 had, and list some proteins which have the same functions with NUP214. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| nucleocytoplasmic transporter activity | XPO1,UPF3A,TPR,NUP160,NUP153,NUP133,TPRB,NUP54,RBM22,NUP107 |
| nuclear localization sequence binding | TNPO1,KPNA1,IPO4,KPNB3,IPO5,KPNA3,KPNA4,RANBP6,KPNA5,IPO13 |
Interacting Protein
NUP214 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NUP214 here. Most of them are supplied by our site. Hope this information will be useful for your research of NUP214.
RAE1;NUP188;NUP93;NUP88;OGT;NUP214;NUP98;pp7052;NUP155;KRT75;HEXB;NUP62;RANGAP1;NUP153;RANBP2;STAT2
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References
- Copeland, AM; Newcomb, WW; et al. Herpes Simplex Virus Replication: Roles of Viral Proteins and Nucleoporins in Capsid-Nucleus Attachment. JOURNAL OF VIROLOGY 83:1660-1668(2009).
- Paulillo, SM; Powers, MA; et al. Changes in nucleoporin domain topology in response to chemical effectors. JOURNAL OF MOLECULAR BIOLOGY 363:39-50(2006).
