NUMBL
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Official Full Name
numb homolog (Drosophila)-like -
Overview
Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons. -
Synonyms
NUMBL;numb homolog (Drosophila)-like;NBL;CAG3A;CTG3a;NUMBR;NUMB-R;TNRC23;NUMBLIKE;numb-like protein;numb homolog-like;numb-related protein
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- Non
- GST
- His
- Myc&DDK
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| NUMBL-1410H | Recombinant Human NUMBL | E.coli | Human | Non | ||
| NUMBL-1411H | Recombinant Human NUMBL, GST-tagged | E.coli | Human | GST | 0-280AA | |
| NUMBL-2030Z | Recombinant Zebrafish NUMBL | Mammalian Cell | Zebrafish | His |
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| NUMBL-673H | Recombinant Human NUMBL | Mammalian Cell | Human | His |
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| NUMBL-1981H | Recombinant Human NUMBL Protein, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
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| NUMBL-3700H | Recombinant Human NUMBL Protein, His (Fc)-Avi-tagged | HEK293 | Human | His&Fc&Avi |
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| NUMBL-3700H-B | Recombinant Human NUMBL Protein Pre-coupled Magnetic Beads | HEK293 | Human |
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| Numbl-4548M | Recombinant Mouse Numbl Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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| NUMBL-5304H | Recombinant Human NUMBL Protein (Ala60-Lys204), N-His tagged | E.coli | Human | His | Ala60-Lys204 |
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| NUMBL-900H | Recombinant Human NUMBL Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
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Involved Pathway
NUMBL involved in several pathways and played different roles in them. We selected most pathways NUMBL participated on our site, such as Notch signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with NUMBL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Notch signaling pathway | MFAP2,ADAM17,HER15.1,LNX1,MYCBP,RBPJ,DLA,HDAC1,JAG1A,DTX3L |
Protein Function
NUMBL has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NUMBL itself. We selected most functions NUMBL had, and list some proteins which have the same functions with NUMBL. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | C9orf86,TNFAIP1,HPS4,HIST1H3A,TBCEL,ROS1,SH3GL1,KLRK1,RFC5,EXD1 |
Interacting Protein
NUMBL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NUMBL here. Most of them are supplied by our site. Hope this information will be useful for your research of NUMBL.
RBFOX1;EGFR;PSMA3;TRAF5;BHLHE40;GAA;ACTN1;THPO;ATXN1;RIPK1;TMC5;spoIVA;SIAH1;ESRP2;TAB2;GPATCH8;TRAF6;MAGED1
Resources
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References
- Ahmad, SM; Tansey, TR; et al. Two Forkhead Transcription Factors Regulate the Division of Cardiac Progenitor Cells by a Polo-Dependent Pathway. DEVELOPMENTAL CELL 23:97-111(2012).
- Gulino, A; Di Marcotullio, L; et al. The multiple functions of Numb. EXPERIMENTAL CELL RESEARCH 316:900-906(2010).
