NUF2
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Official Full Name
NUF2 NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae) -
Overview
Nuf2 is a component of kinetochore-associated Ndc80 complex which serves to attach microtubules to the kinetochore. Nuf2 is a conserved protein from yeast to human. Disruption of the Nuf2 gene in Schizosaccharomyces pombe causes defect in chromosome segregation and in the spindle checkpoint. Yeast Nuf2 disappears from the centromere during meiotic prophase when centromeres lose their connection to the spindle pole body and plays a regulatory role in chromosome segregation. In human cells Nuf2 specifically functions at kinetochores for stable microtubule attachment. Down regulation of the protein by RNA interference results in failure of the kinetochores to form attachments to the spindle microtubules. As a result cells are blocked in the prometaphase stage with an active spindle checkpoint and undergo cell death. -
Synonyms
NUF2;NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae);CDCA1, cell division cycle associated 1;kinetochore protein Nuf2;cancer/testis antigen 106;CT106;NUF2R;hNuf2;hNuf2R;hsNuf2;cell division cycle associated 1;cell division cycle-associated protein 1;CDCA1
Recombinant Proteins
- Zebrafish
- Mouse
- Human
- Rhesus macaque
- Rat
- Chicken
- Mammalian Cell
- Wheat Germ
- E.coli
- HEK293
- In Vitro Cell Free System
- His
- GST
- Non
- His&Fc&Avi
Involved Pathway
NUF2 involved in several pathways and played different roles in them. We selected most pathways NUF2 participated on our site, such as Cell Cycle,Cell Cycle, Mitotic,M Phase, which may be useful for your reference. Also, other proteins which involved in the same pathway with NUF2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Mitotic Anaphase | LEMD3,MLF1IP,CENPK,RANGAP1B,VRK2,CENPO,CENPE,CDCA5,ZWINT,CENPL |
| RHO GTPase Effectors | ABI1A,SPDL1,ZWILCH,KLC3,PMF1,KDM4C,NSL1,CDCA8,ZWINT,IQGAP3 |
| RHO GTPases Activate Formins | SPDL1,ZWINT,DSN1,EVL,NSL1,SKA1,SKA2,MIS12,NDEL1B,MKL1 |
| Mitotic Prometaphase | PANE1,SMC2,RCC2,SPC25,CDCA8,SKA1,AHCTF1,SPC24,NDEL1A,NCAPG |
| Mitotic Metaphase and Anaphase | KNTC1,ITGB3BP,PANE1,CENPH,ZW10,CENPQ,MLF1IP,SGOL1,NDEL1A,ERCC6L |
| Cell Cycle, Mitotic | KIF2B,CDT1,CSNK2A2,CDKN2B,KIF18A,GOLGA2,MAPRE1A,HIST4H4,ITGB3BP,MYBL2 |
| M Phase | NCAPG2,TMPO,INCENP,MAU2,NCAPG,CENPH,SMC2,SGOL2,ITGB3BP,NEK9 |
| Cell cycle | HIST2H3C,CNEP1R1,MDM2,ORC3,PIANP,ANAPC13,SMC1B,WRAP53,TTK,FOXM1 |
Protein Function
NUF2 has several biochemical functions, for example, molecular_function,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NUF2 itself. We selected most functions NUF2 had, and list some proteins which have the same functions with NUF2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| molecular_function | TMEM251,GM13057,OTULINA,RSRP1,ILVBL,PNPLA4,MAGEA5,LHFPL2A,GM7861,DIRC2 |
| protein binding | Tnfrsf22,HIST1H3F,TTLL10,SLX4IP,GLRB,GPANK1,SMAP2,DROSHA,USP8,STAC3 |
Interacting Protein
NUF2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NUF2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NUF2.
NDC80;CENPE
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References
- Knowlton, AL; Vorozhko, VV; et al. ICIS and Aurora B Coregulate the Microtubule Depolymerase Kif2a. CURRENT BIOLOGY 19:758-763(2009).
- Stucke, VM; Baumann, C; et al. Kinetochore localization and microtubule interaction of the human spindle checkpoint kinase Mps1. CHROMOSOMA 113:1-15(2004).
