NUDT4

  • Official Full Name

    nudix (nucleoside diphosphate linked moiety X)-type motif 4

  • Overview

    The protein encoded by this gene regulates the turnover of diphosphoinositol polyphosphates. The turnover of these high-energy diphosphoinositol polyphosphates represents a molecular switching activity with important regulatory consequences. Molecular switching by diphosphoinositol polyphosphates may contribute to regulating intracellular trafficking. Several alternatively spliced transcript variants have been described, but the full-length nature of some variants has not been determined. Isoforms DIPP2alpha and DIPP2beta are distinguishable from each other solely by DIPP2beta possessing one additional amino acid due to intron boundary skidding in alternate splicing.

  • Synonyms

    NUDT4;nudix (nucleoside diphosphate linked moiety X)-type motif 4;diphosphoinositol polyphosphate phosphohydrolase 2;diphosphoinositol polyphosphate phosphohydrolase type 2;DIPP2;DIPP2alpha;DIPP2beta;HDCMB47P;KIAA0487;Diadenosine 5 5 P1 P6 hexaphosphate hydrolase 2;DIPP 2;DKFZp686I1281;Nucleoside diphosphate linked moiety X motif 4;Nudix (nucleoside diphosphate linked moiety X) type motif 4;Nudix motif 4;Nudix type motif 4;NUDT 4;DIPP-2;OTTHUMP00000243079;OTTHUMP00000243080;OTTHUMP00000243082;OTTHUMP00000243083;OTTHUMP00000243084;diadenosine 5,5-P1,P6-hexaphosphate hydrolase 2;diphosphoinositol polyphosphate phosphohydrolase type

Recombinant Proteins

  • Rhesus macaque
  • Rat
  • Human
  • Mouse
  • Mammalian Cell
  • E.coli
  • HEK293
  • HEK293T
  • His
  • Non
  • Myc&DDK
  • His&Fc&Avi

    Involved Pathway

    NUDT4 involved in several pathways and played different roles in them. We selected most pathways NUDT4 participated on our site, such as Inositol phosphate metabolism,Metabolism,Synthesis of pyrophosphates in the cytosol, which may be useful for your reference. Also, other proteins which involved in the same pathway with NUDT4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Synthesis of pyrophosphates in the cytosol NUDT3A,NUDT11,NUDT4A,NUDT10,NUDT3B,NUDT4B,NUDT3,IP6K3
    Inositol phosphate metabolism PIP5KL1,IMPA1,INPPL1A,MTMR2,MINPP1,SYNJ2,PLCB4,PIP5K2,PIK3CB,NUDT4A
    Metabolism COX4I1,ACY3.1,ACOT11A,DGUOK,CHKB,SLC23A2,LYRM4,ADSS,SLC2A3,NUDT3A

    Protein Function

    NUDT4 has several biochemical functions, for example, diphosphoinositol-polyphosphate diphosphatase activity,inositol diphosphate tetrakisphosphate diphosphatase activity,inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NUDT4 itself. We selected most functions NUDT4 had, and list some proteins which have the same functions with NUDT4. You can find most of the proteins on our site.

    Function Related Protein
    diphosphoinositol-polyphosphate diphosphatase activity NUDT11,NUDT3,NUDT10
    protein binding CELF1,GTF3C4,ARMCX1,ATF7,WASH1,CRMP1,SEC24A,LINC00482,VPREB1,KCNK16
    inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity NUDT10,NUDT3,NUDT11
    NOT m7G(5)pppN diphosphatase activity NUDT1,NUDT16L1,NUDT5,NUDT7
    inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity NUDT10,NUDT3,NUDT11
    snoRNA binding NHP2,IMP4,NUDT5,NOP10,TBL3,NUDT7,NUDT16L1,NUDT16,NUDT1,HEATR1
    inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity NUDT10,NUDT11,NUDT3
    metal ion binding EBF1,NLN,ALDH1A2,CEPT1,ADK,ACVR1,NR2F6B,ZNF544,MGAT4C,NME6
    inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity NUDT3,NUDT11,NUDT10

    Interacting Protein

    NUDT4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NUDT4 here. Most of them are supplied by our site. Hope this information will be useful for your research of NUDT4.

    KEAP1;1-phosphatidyl-1d-myo-inositol 3,4,5-trisphosphate

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